go Veterinary Medicine. 



dietary must be secured. The system that is full of strength and 

 vigor can better resist the microbe and even throw it off entirely,, 

 whereas the weak, confined subject succumbs. For the same 

 reason, the weak, emaciated and debilitated subjects should be at. 

 once separated from the sound flock, and kept in a special enclo- 

 sure, in the open air, on a rich diet. Should they harbor worms,, 

 this seclusion is even more imperative. (See parasites of lungs, 

 liver, stomach and bowels). 



Ivignieres advocates immunization by serum prepared on the 

 Pasteur method, but, as he has not divulged the exact technique 

 of its preparation, it is impossible as yet, to give this an unquali- 

 fied endorsement. It has this in its favor that the mature sheep, 

 in full vigor of middle life, though in an infected area, usually 

 resist the infection, while the young, old, debilitated and vermin- 

 ous suffer. Opposed to it are these considerations that are recog- 

 nized by lyignieres himself ; — rst. The acquired immunity is not 

 perfect, as shown by occasional relapses in sheep that have sur- 

 vived a first attack ; 2d. The serum inoculation is not only use- 

 less, but dangerous in animals that already harbor the germ ; I 

 may add 3d. Any acquired parasitism or debilitating disease may 

 tend to break down the immunity and prostrate the system under 

 the infection. ■ I,ignieres advises that the serum treatment should 

 be restricted to the new born lambs in infected herds, or herds in 

 infected areas. The first three or four weeks after birth are to- 

 be preferred for the operation, though failing this, it may still be 

 ventured on, up to a few days before weaning. The longer it is 

 delayed the greater the danger of a preexisting" infection, and of 

 untoward results from the new access of infecting material, on 

 the back of an infection which varies so extremely in its patho- 

 genic potency. Even among the new born lambs, I,ignieres- 

 would restrict the serum therapy to the strong, robust and healthy, 

 and, if they survive the resulting fever, would repeat the treat- 

 ment after the hyperthermia has ceased. No satisfactory treat- 

 ment of the disease has been made. An open air life, a generous 

 diet, and a course of iron, and bitters will, however, be of use in 

 serving to improve health, digestion and vigor, to solicit a better 

 production of red globules, and to enable the patient to survive 

 the period of anaemia, prostration and debility. Antiseptics like 

 quinia, the sulphites and the iodides might be used as adjuncts^ 



