92 Veterinary Medicine. 



arrival of the sick pigs and escaped, and on another a second 

 flock kept in outlying pens well apart from the home flock kept 

 perfectly sound. 



With cultures of the microbe in vitro, he successfully inoculated 

 sheep, goats, dogs, chickens, Guinea pigs, rabbits, and, finally, 

 a calf and an ass. The cultures were inoculated in different cases ; 

 intravenously, into the trachea, pleura, lung, and subcutaneous 

 connective tissue, and one goat was infected by ingestion. 



Ivignieres claims that Galtier must have worked with a complex 

 infection in which his (I^ignieres' ) cocco-bacillus was an essential 

 constituent. The evidence of this is, however, lacking, and we 

 must recognize that Galtier made cultures which showed the close 

 relationship of his organisms to swine plague, and their lack of 

 complete identity with those of the I^ombriz. The filtrable mi- 

 crobe of hog cholera was probably present. 



I^ienaux and Conte had pathogenic results in a limited number 

 of animals only (rabbit, mouse, guinea pig) illustrating the fa- 

 miliar truth of the variability in the pathogenesis of different 

 specimens of septicsemic bacteria of the colon group. 



Symptoms, i. Acute Form. There is a sudden marked rise 

 of temperature, often to 107° F., with acceleration of pulse and 

 respiration. Sometimes death follows so early so as to prevent the 

 observation of other symptoms. If otherwise, there supervene 

 marked dulness, prostration, somnolence, anorexia, suspension of 

 rumination, and more or less tympany of the rumen. The 

 patient is found lying down, apart from the flock, indisposed to 

 rise, with deep red, congested, arborescent conjunctiva and other 

 mucous membranes, and petechial spots on these and on the white 

 portions of the skin. The faeces, at first moderately firm and 

 moulded in pellets, marked here and there with lines of mucus, 

 or even blood, become on the second or third day soft, pultaceous, 

 or watery and highly offensive. Parallel with this, emaciation 

 advances with rapid strides. Breathing becomes more hurried, 

 wheezing or snuffling, with a muco-serous, often bloody discharge 

 from the nose, and an infrequent cough. Careful auscultation 

 and percussion will often reveal the blowing or mucous r^les, the 

 crepitation or flatness on percussion of broncho-pneumonia. As 

 the disease advances the petechise on skin and mucosae extend, 

 and extensive deep violet areas show especially on the inner sides 



