Glanders in Man. 285 



and by eating his flesh. The disease has also been conveyed 

 from dog to dog by licking each other. In many cases even in- 

 oculated glanders produces only a local ulcerous inflammatory 

 lesion with or without hard swelling of the adjacent lymphatics, 

 and engorgement of the lymph glands. After a rather tardy 

 granulation and cicatrization, the symptoms subside and the 

 animal is restored to health. Yet such benignity does not depend 

 on any lessened virulence of the bacillus, for an inoculation of the 

 discharges on the ass produces acute and fatal glanders. 



GI.ANDERS IN MAN. 



Recognized by Lorin 1812. Causes : infection from soliped, man less sus- 

 ceptible ; infection from man, clothing, stable bucket, inhalation, etc. ; in- 

 dustrial disease ; native immunity. Symptoms : incubation ; mistaken for 

 carbuncle, small pox, measles, erysipelas, anthrax ; anamnesis ; anthrax 

 focus has darker center, no caseation, no corded lymphatics ; nodules and 

 ulcers in nose, swollen submaxillary glands and lymph vessels, general ill- 

 ness, diarrhoea, vomiting, dyspnoea, me&tal derangement, stupor, coma, in- 

 ternal deposits, bloody sputa, foetid breath, hepatic pain, icterus, muscles, 

 bones, bowels, typhoid, pyaemic, osteo myelitic, or acute tuberculous symp- 

 toms. Death in 3 days to 4 weeks. Chroniccases, cutaneous, muscular, osse- 

 ous, skin nodules in group or chain, glandular swellings. Diagnosis from 

 pyaemia by lack of chills, and the sanious pus ; from syphilis by futility of 

 potassium iodide, and history ; inoculate ox or white mouse ; find bacillus. 

 Lesions : as in horse, more early coagulation necrosis, ulceration, abscess ; 

 pus more viscid than in pysemia, walls of abscess more irregular, lymphoid 

 cell proliferation more abundant and extended (glands, spleen, liver, lung, 

 nose, etc.), history ; distinguished from variola, rotheln, and erysipelas by 

 the many miliary or pea-like neoplasms with cellular caseating centres ; 

 lymphoid deposits in bone marrow, with friability. 



Until the early part of the present century glanders in man was 

 not traced to its origin in the sohped. lyorin in 1812 recorded a 

 case in which the human hand had been accidentally inoculated 

 from handling a horse suffering from farcy. Soon other cases 

 were put on record by Waldinger and Weith, Muscroft, Schilling, 

 Rust, Sedow, and a host of followers. lyater Rayer, Tardieu, 

 Virchow, I^eisering, Gerlach and Koranye have thrown much 

 light on the subject. 

 "' Etiology Man is manifestly less susceptible than the soliped. 



