Prophylaxis and Treatment of Glanders. 295 



Pilavios, Bonome and Vivaldi, Johne, Schindelka, Prieur and 

 others record recoveries in recent cases and there need be no doubt 

 of its value in subjects that are naturally somewhat refractory to 

 the germ. Babes introduced the blood serum of the ox, which is 

 naturally immune, and Prieur speakes with confidence of the 

 treatment of cutaneous glanders in man and certain cases of 

 pulmonary glanders in the horse. 



TREATMENT IN MAN. 



The surgical treatment of glanders in man does not differ ma- 

 terially from that given for animals. It is more frequently 

 possible to deal with the local lesion in its early stages and then 

 a thorough cauterization of the infected sore, and a little later the 

 complete excision of the primary nodule, or the limited regional 

 infiltration, the curetting of the adjacent parts and the rnainten- 

 ance of thorough disinfection by irrigation, sponging and compress 

 will often be followed by success. Where such radical measures 

 are inadmissible the infected parts should be excised and curretted 

 as far as safe and the adjacent parts subjected to carbolic in- 

 jections (i :2oo). Abscesses should be evacuated, fistulas slit 

 open, and thorough disinfection applied For the affected air- 

 passages, iodoform insufflations and antiseptic gases, sprays, and 

 solutions should be freely used. 



Internally, antiseptics such as sulphocarbolates and tincture of 

 muriate of iron, iodides, and carbolic acid have been largely em- 

 ployed. Whitla recommends 5 grains of quinia in 15 grains of 

 tincture of muriate of iron every four hours. Tonics (arsenate of 

 strychnia), and stimulants, ammoniacal or alcoholic, may be 

 called for. Special symptoms such as pain, rigors, nausea, vomit- 

 ing, diarrhoea and profuse perspirations must be met by suitable 

 remedies. Finally blood serum from healthy cattle or from im- 

 munized animals may be employed subcutem. Pure air and 

 nourishing, easily digestible food are very essential. Every effort 

 should be made to check the disease at its outset, as generalized 

 acute glanders is speedily fatal, and recoveries in chronic cases 

 usually leave a broken down constitution. 



