^86 Veterinary Medicine. 



had just died of smallpox, on a cow's udder, and subsequent^'- 

 inoculated about fifty persons from the eruption caused in the 

 cow. Most of those so inoculated had unmistakable smallpox 

 and three died. Reiter had a very similar experience. 



Chauveau (French Commission) inoculated twelve susceptible 

 cattle with smallpox virus and produced, in all but one, small 

 conical (smallpox) papules and vesicles, and in ten of these, on 

 subsequent inoculation with cowpox, six proved immune, three 

 had rudimentary pustules, and one had a distinct cowpox eruption. 



A milch cow and two heifers were inoculated with smallpox 

 and cowpox on two sides of the vulva, with the result that each 

 disease appeared in the seat of its inoculation, with its character- 

 istic vesicles, and the.two developed side by side. The smallpox 

 vesicles were by inoculation conveyed from ox to ox, with stead- 

 ily decreasing activity. Inoculated from the cow on a child, it 

 caused great hyperthermia, vomiting, one large vesicle like vac- 

 cinia and a general eruption like varioloid. Inoculation from 

 this child upon another produced a mixed eruption of cowpox 

 and varioloid. Inoculation from the second child on a bull and 

 heifer produced papular eruption only. 



Smallpox virus, inoculated on a horse produced a papular erup- 

 tion, but failed to affect another horse that had been previously 

 vaccinated. Cowpox virus inoculated on the first horse which 

 had had the papular eruption, caused a second papular eruption 

 (not cowpox). The virus from a vesicle in the first horse caused 

 a similar eruption in another horse, on which it was inoculated. 

 The lymph from the papular eruption led to a similar eruption in 

 cattle, on which it was inoculated, but did not protect against 

 cowpox, subsequently inoculated. 



The lymph from the papular eruption in the horse, inoculated 

 on two children, produced fever, vomiting, a general papular 

 (smallpox) eruption, in which a few of the pustules only showed 

 a tendency to umbilication. A child and its mother in the same 

 ward contracted varioloid. A child inoculated from one of the 

 first named children, had six large umbilicated vesicles like cow- 

 pox and a general papular (smallpox) eruption. Another child 

 inoculated from the last had six large umbilicated vesicles, and a 

 general papular (smallpox) eruption. From the papular erup- 

 tion of one of these children a horse and seven cattle were inocu- 

 lated and in all a varioloid eruption resulted. 



