Dourine. 573 



are numerous and hyperplasia is often present, The neuroglia 

 especially tends to encrease, and apart from the foci of softening 

 tends to give a special firmness to the substance. At intervals, 

 in the perivascular spaces, may often be found minute (micro- 

 scopic or macroscopic) blood clots. The subarachnoid and sub- 

 dural fluid is encreased and may be pinkish. At the roots of 

 spinal nerves, especially in the dorsal and lumbar regions, a gela- 

 tinoid exudate may invest the nerve, distending the connective 

 tissue beneath the neurilemma and even occupying the interval 

 between the nerve filaments. Sometimes large corpuscular 

 bodies are found between the nerve fibres. 



The cerebral meninges, especially the/z'a mater are congested 

 and opaque. Foci of softening are by no means uncommon and 

 the cerebral ventricles contain an abnormal quantity of fluid. 



The bony tissue generally has lost its consistency and the medul- 

 lary matter may be unduly reddened. The large joints contain 

 an excess of synovia somewhat pinkish in color, and the liga- 

 ments of the hip joints are often congested, thickened and soften- 

 ed. The articular cartilage may even show patches of blood 

 staining. 



The intestines are usually nearly empty, soft, pale and flaccid, 

 and Ruthe has in one case observed rounded ulcers on the mucosa. 

 Fibroid thickening on the peritoneal surface may indicate a pre- 

 vious exudate. 



The mesentery is thickened, with infiltration and has a yellow- 

 ish discoloration and the mesenteric glands are usually enlarged, 

 softened and friable, though sometimes firm and contracted. The 

 lymph glands adjoining the generative organs are often swollen, 

 pigmented and studded with foci of caseation, varying in size from 

 a pea upward. 



The liver is softened and congested or fatty. The spleen is 

 small. 



The kidneys are usually large, but flaccid, pale and bleached. 



The thoracic organs may show little change, though hypostatic 

 inflammation and foci of caseation or suppuration may be present. 



The ^/(7(7ia? is pale and watery and forms a loose, pale, diffluent 

 clot, while there is an extraordinary diminution of red globules 

 and a relatively great encrease of leucocytes eosinophiles. 



In advanced stages the muscles are pale, anaemic and shrunken 

 especially those of the hind limbs. 



