Mai de. Caderas. 585 



Lesions. The pale coloress blood is often characteristic. The 

 normally light colored tissues (serosse, mucosae, adipose tissue, 

 etc. , are abnormally white or yellow. The muscles are pale and 

 atrophied especially in the hind quarters. The intermuscular 

 tissue often shows a gelatinoid exudation, and in the gluteal 

 region points of haemorrhage may be found. There is enlarge- 

 ment of the liver, spleen and lymph glands, and pallor of the kid- 

 neys with points of congestion. The heart is soft, flabby and on 

 the endocardium petechiated. A slight serous effusion may be 

 present in the chest, abdomen or pericardium. 



Diagnosis must be based on the very characteristic symptoms 

 and on the lesions, but above all on the presence of the haemato- 

 zoon during and immediately after each access of fever. Or 

 inoculation of a dog or Guineapig may be resorted to. 



Treatment proved a continuous failure. Quinine and cacody- 

 lates by the mouth and subcutem were equally ineffective. 



Prevention. Calendrini claimed excellent results from the 

 killing and burial of the diseased, the separation of all sound 

 horses from the places where they had been, and the thorough 

 •disinfection of all harness, utensils, wagons, etc. For a number 

 of years his district (Soure) was, by this means, kept free from 

 the plague. The precautions recommended under Surra would 

 be equally applicable here. Above all remove all manure and 

 rubbish heaps, or seclude them in close dark pits where they can 

 be disinfected, apply to the skins of the animals preparations of 

 naphthalin, tar or other agent obnoxious to the insects, .and 

 screen the stables against their invasion. Fly covers should be 

 worn when abroad. Petroleum may be sprinkled on all stagnant 

 water, devoid of fishes and frogs, to kill the mosquitoes. Stable 

 vermin, caviai, dogs, water hogs and Guineapigs should be sub- 

 jected to the measures for suppression. Agglutination of the 

 haematozoa is determined by the serum of strongly immunized 

 cattle, sheep and swine, but attempts to avail of this in the 

 immunization or therapeutics of the horse have not proved satis- 

 factory. 



