626 Veterinary Medicine. 



preserved and their eggs hatched in an incubator. The resultant 

 six legged larvae, placed on susceptible puppies a month old 

 proved harmless and no protozoa appeared in their blood. This 

 was repeated when the same generation of ticks had reached the 

 stage of nympha, and it was after two months from the hatching 

 that the ticks, now mature, when placed on the same puppies 

 conveyed the disease. On the thirteenth day the temperature 

 reached 105" F., and the red globules swarmed with parasites, 

 many single globules containing no fewer than eight. They were 

 of various shapes, spherical, pyriform or cloveshaped many 

 tapering finely toward the ends like an oat. The puppies died 

 respectively 14 and 18 days after infection. 



Experiments made on other dogs with the larval and mature 

 ticks, fully confirmed the conclusion that the immature insect 

 was harmless. A 14' days old puppy infected by mature ticks 

 died on the nth day so that the immunity of the other puppies 

 cannot be due to a milk diet, as in<the case of calves and Texas 

 fever. Intravenous inoculation with the infected blood invariably 

 conveyed the disease. Even mature ticks grown from eggs of 

 those fed on infected and sick dogs are not always infecting. All 

 the eggs do not receive the piroplasma. Jackals are exempt- 

 (l/ounsbury). 



Symptoms. On the third day after inoculation the dog is dull, 

 prostrate, apathetic and drowsy, refuses food and shows thirst. 

 Temperature may reach 103° to 106° F. On the fourth day 

 the mucosae assume a yellowish tinge, and by the fifth this has 

 encreased to a deep chrome yellow, which involves any white 

 portions of the skin as well. Haemoglobinuria is now well de- 

 veloped, the liquid being often as dark as claret, and the patient 

 may lie perfectly prostrate, giving off an offensive odor from the 

 skin, lungs, and especially from the mouth. The tongue is 

 furred, the teeth dirty, and the gums may be congested or even 

 ulcerated. Emaciation advances rapidly. The temperature may 

 oscillate from day to day or it may rise steadily to a climax, and 

 then descend suddenly when collapse occurs. In all cases the pro- 

 tozoon is found in the red globules, or free in the blood. In the 

 worst cases the red globules may be so reduced in number that 

 they can scarcely be found. Death comes usually by collapse. 

 In some instances the haemoglobinuria may be absent yet the 

 disease advances to a fatal result. 



