636 Veterinary Medicine. 



(Steel, Ivingard), encrease of fluid in the arachnoid or lateral 

 ventricles, or in the spinal cord, with gelatinoid exudation in the 

 lumbar portion (Lingard), Like other tissues, in advanced 

 stages the nerve centres are usually anaemic (Geo. H. Evans). 



Ineubation. As made out by inoculation cases this extends 

 from two to eight days, according to the dose — five to seven days 

 being the most common. Infection by inoculation subcutem in 

 mules showed a hyperthermia on the fifth day ; or by ingestioi; 

 (feeding the virus) on the sixth day (Steel). Longer (alleged) 

 incubation depends mainly on the first slight paroxysms having 

 been overlooked, or set down for the frequent bilious or icteric 

 condition which is common in mules and horses in India (Steel), 

 or to a later infection by insects or otherwise. 



Symptoms. In experimental cases a small raised swelling iif 

 the seat of the inoculation, appears in 24 hours, encreasing to 2 

 to 4 inches in diameter, and i to i J^ inch high by the 4th day, 

 and loosely connected with the parts beneath. From the 4th to 

 the 14th day it decreases in size and softens and general symptoms 

 set in. 



In casual cases these general symptoms are the first to be 

 observed. There is transient fever 102" to 104°, highest toward 

 night and without preliminary chill, hot mouth and skin, dulness, 

 sluggishness, inappetence, yellowness of the mucosae, petechise 

 on conjunctiva or vulva, and sometimes nodules like those of 

 urticaria on the skin. After a day or two these symptoms 

 subside, the temperature is loi" F., or below, the mucosae 

 clear and pale, and spirit and appetite nearly normal. These 

 slight first paroxysms are rarely seen by the veterinarian, having 

 been looked upon as one of the oft-recurring bilious attacks of a 

 hot climate. The remission lasts for 3 to 10 days when the 

 second paroxysm sets in, like the first but often more marked ; 

 temperature 102° to 104°, .eyes especially the membrana nictitans 

 petechiated, epiphora, slight catarrh from nose or vulva, it may 

 be stocking of the legs, or pitting swelling under the breast bone, 

 or abdomen, or in the sheath. Like the first, the second paroxysm 

 subsides, and after another interval a third sets in, to be followed 

 in like manner by a fourth, a fifth and so on, if the patient sur- 

 vives. With each the symptoms become more pronounced, the. 

 mucosae are left more pale and bloodless, debility and weakness 



