Actinobacillosis. 695 



treatment shows that no mere chemical poison maintains the 

 destructive process, for it is manifestly the microbicide which 

 puts a prompt limit to the disease, and under such treatment no 

 sphacelating agent in the blood or tissues keeps up the advance 

 of the ulceration or prevents healing. 



Treatment. The ulcers healed rapidly under cleanUness and 

 antiseptic applications. The tail, anus, and vulva were washed 

 with tepid water, and then dressed with a solution of creolin 

 (5:100), or carbolic acid (3:100), or mercuric chloride (1:500 or 

 1000). The ulcers were touched with a pencil of silver nitrate. 

 S. T. Miller followed the sublimate lotion by the subjoined oint- 

 ment : iodoform 20 grains, eucalyptol 40 minims, phenic acid 20 

 minims, petrolatum enough to make 2 oz. C. Miller in addition 

 to the carbolic acid lotion applied the common white lotion (zinc 

 sulphate i oz., lead acetate i oz., water i qt.) and used silver 

 nitrate on the ulcers. Four dressings on four successive days were 

 given and in the milder cases healing was completed in 10 or 12 

 days. 



ACTINOBACII.I.OSIS. 



Lignieres and Spitz describe a disease of cattle in Argentina, 

 which resembles actinomycosis, in the organs invaded, the steady 

 progress by the invasion of different tissues indiscriminately, the 

 hardness of the advancing growth, the presence of minute 

 granules or tufts of clubbed cells radiating from a centre, and 

 the absence of any general poisoning by specific toxins. It 

 differs in being due to a bacterium (bacillus) in place of actino- 

 myces, in invading the adjacent lymph glands, and in being 

 more easily inoculated. 



It is reported by the discoverers, I/ignieres and Spitz, as epi- 

 zootic in Argentina, while Nocard recognized it in France and 

 Higgins in Canada. 



Bacteriology. The microbe is rod shaped, i to 2/x by 0.4/*, 

 aerobic, facultative anaerobic, non-motile, non-sporulating, stains 

 easily in phenic fuchsin, picro carmine, and acid violet, bleaches 

 in Gram's, grows at 37" C. in peptonized bouillon without pro- 

 ducing acid or odor, acidifies lactose and glucose, and dies in 10 

 minutes at 143.6° F. 



