MADURA DISEASE 333 



mycelium. Microscopically the parasite appears as a mycelium 

 of thick branching filaments with delicate transverse septa ; in 

 the older threads the segments become swollen, so that strings of 

 oval-shaped bodies result. No signs of spore-formation were 

 noted. Inoculation of animals with cultures gave negative 

 results, as did also direct inoculation with the black granules 

 from the tissues. Brumpt, in a recent work, distinguishes 

 several varieties of parasite concerned in Madura disease, and 

 finds that a pale variety may be produced by a hyphomycete 

 as well as by Vincent's streptothrix ; in fact, with the exception 

 of Vincent's organism, all the parasites are considered by him to 

 be closely allied to aspergillus. 



