518 



SYPHILIS 



Noguchi, on studying different strains of the sp. pallida in 

 cultures, found that they varied in thickness, and he was able to 

 distinguish thick, thin, and intermediate types. He also found 

 that they differed in their pathogenic action, the thick forms on 

 injection into the testicle of a rabbit causing nodular lesions of 

 cartilaginous hardness, the thin forms producing a diffuse in- 

 durative lesion. These observations are suggestive as possibly 

 throwing some light on the variations in the effects in the 

 human subject. 



The number of publications with regard to the distribution of 



Pig. 159. — Section of spleen from a ease of congenital syphilis, 

 showing several examples of spirochete pallida. Levaditi's method. 

 X2000. 



the spirochsete pallida is now very large, and a summary of the 

 results may be given. In the primary sore and in the related 

 lymphatic glands, the juice of which can be conveniently 

 obtained by means of a hypodermic syringe, the organism has 

 been found in a very large majority of cases. It has been also 

 obtained in the papular and roseolar eruptions, in condylomata 

 and mucous patches — in fact, one may say generally, in all the 

 primary and secondary lesions. Schaudinn in his last series of 

 cases, numbering over seventy, found it in all, and on a few 

 occasions detected it in the blood during life in secondary syphilis. 

 It has also been obtained from the spleen during life. In the 

 congenital form of the disease the organism may be present in 



