548 



PATHOGENIC FUNGI 



While organisms of this group have been isolated from many 



conditions, for example 

 rabies and malignant 

 — tumours, in which there 



is no evidence that they 

 play an etiological role, 

 there is no doubt that 

 they can multiply and 

 originate pathological 

 changes in the animal 

 body. An example of 

 this is seen in Fig. 

 172, taken from the 

 kidney of a rabbfy 

 which was inoculate^ 

 subcutaneously with 

 an organism isolated 

 from the sputum of a 

 human case of obscure 

 granuloma of the lung, 

 associated with a sup- 

 the presence of similar 



^StftiX* 



Fig. 172. — Growth of blastomyces in kidney 

 of rabbit infected from human case (see text). 

 XlOOO. 



purative condition in the 

 organisms in the urine. 

 In this case the appear- 

 ances of the organisms 

 in the tissues corre- 

 sponded to those seen 

 in cultures.- In the 

 conditions about to be 

 described, and of which 

 we have had no personal 

 experience, difficulties 

 present themselves in 

 that the supposed causal 

 agent appears in the 

 tissues in the form of a 

 peculiar round double- 

 contoured cell (Fig. 173) 

 not exactly reproducible 

 in artificial cultures. 

 The appearances of 

 these cells are rather 



kidney, and 



A 



Fig. 173. — Double-contoured bodies in tissues 

 from one of Rixford and Gilchrist's cases. 

 X 500.1 



1 For the tissue from which this preparation was made we are indebted to 

 Dr. Rixford. 



