LIQUOR CRESOLIS COMPOSITUS 253 



given on an empty stomach, in a quart of water, is one of the most effec- 

 tive vermifuges for the horse. ^ 



LiQuoa Cresolis CoMPoaiTus. (U. S. P.) Compound Solution of Cresol. 

 ' Synonym, Lysol (Proprietary Name). 



Cresol, 500 Gm.; linseed oil, 800 Gm.; potassium hydroxide, 80 Gm.; alcohol, 

 80 Gm.; water, to make 1000 Gm. 



Synonym.— Liquor cresoli saponatus, P. G.; solute de crgsol composS, Fr.; 

 kresolseifenlosung, G. 



Derivation.— From that part of tar oil which boils between 190° and 200° C, 

 by dissolving in fat and saponifying in alcohol. 



Properties. — A clear, brown, oily liquid, of a feeble, creosote-like odor. Solu- 

 ble in water, forming a clear, frothy, soapy fluid, and in alcohol, chloroform, and 

 glycerin. 



Uses: — Compound cresol solution is used as a substitute for creolin 

 in 1/^ to 2 per cent, aqueous solution. The compound cresol solution is 3 

 times, and lysol but 2.12 times, more germicidal than phenol. (U. S. 

 Hygienic Laboratory.) A 1 per cent, solution of liq. cresol. co. is more 

 effectively antiseptic than a 1 to 1000 solution of mercuric bichloride. 

 The latter requires over one-half hour to kill most pathogenic micro- 

 organisms. One per cent, lysol destroys streptococci within one minute. 

 Two per cent, solutions are useful in irrigating wounds and for making 

 wet dressings and vaginal injections. Lysol should be bought under the 

 official name (liq. cresol. co.), as it is cheaper and more effective than 

 lysol. Solutions do not roughen the surgeon's hands, and instruments 

 submerged in them are not injured or obscured. 



The liquor cresolis compqsitus is perhaps the most widely used and 

 valuable surgical antiseptic and disinfectant at our disposal. 



Betanaphthol. Ci„H,0 H. (U. S. P.) 



Synonym. — Naphthol, E.; naphthol, B. P.; naphtholum, P. G.; naphthol-B, 

 Fr.; beta naphthol, G. 



A phenol occurring in wood tar, but usually prepared artificially from 

 naphthalin. 



Derivation, — Naphthalin is treated with strong sulphuric acid. B-naphthalin 

 sulphonic acid is formed (CmH, H SO3). The latter acid is dissolved in water 

 with milk of lime, and the resulting calcium salt is recovered by crystallization. 

 The crystals are then dissolved in water and treated with sodium carbonate, when 

 sodium naphthalin-.sulphonate (Ci„ H, SO3 Na) results. The latter is mixed with 

 fused sodium hydroxide, when sodium naphtol (CjoH, O Na) and sodium sulphite 

 are obtained. Hydrochloric acid is added to the former, and naphtol results, 

 which is further purified by sublimation and recrystallization. 



Properties. — Colorless, or pale buff-colored, shining, crystalline laminae, or a 

 white, or yellowish-white, crystalline powder; having a faint phenol-like odor, 

 and a pungent taste. Permanent in the air. Soluble in about 1000 parts of 

 water, and in 0.8 part of alcohol; also soluble in ether, chloroform, glycerin, 

 olive oil, or solutions of caustic alkalies. 



Dose.—H., 31i-iii, (8-12); D., gr.i-x, (.06-.6). 



Actions and Uses. — Naphthol is a powerful disinfectant, antiseptic 

 and parasiticide. It is said to be several times more germicidal than 

 phenol. B-naphthol somewhat resembles carbolic acid in its toxic effect. 

 It irritates the mucous membranes, causing sneezing and coughing in the 

 respiratory tract, nausea and diarrhea when swallowed, and acute ne- 

 phritis, with inflammation of the urinary tract and strangury in its elim- 

 ination. It is a useful application externally for mange and ringworm. 



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