SQUILL 339 



a glucoside. (2)^Scilliplcrin. (S) Scillin. In addition the drug contains 

 mucilage. 



Squill Dose.—H., oi-ii, (4-8); C, 3ii-iv, (8-15)'; Sh., gr.xv-xxx, (1-2); D., 

 gr.l-v, (.06-.8). 



PREPARATIOlfg. 



Fluidextractum Scillce. Fluidextract of Squill. (U. S. P.) 

 Made by maceration and percolation with diluted alcohol, alcohol and water, 

 and evaporation. Minimum lethal dose not more than 0.00006 mil for each Gm. of 

 body weight of frog. 



Dose.—H., 3i-ii, (4,-8); C, 3ii-iv, (8-15); Sh., TTlxv-xxx, (1-2); D., 

 rii-v, (.06-.3). 



Tinctura Scillce. Tincture of Squill. (U. S. & B. P.) 

 Made by maceration and percolation of squill, 100; with alcohol and water 

 to malje 1000. Standardized as above. (U. S. P.) 



Dose.—H., 3vi-§iss, (24-45); C, giss-iii, (45-90); Sh., oiss-iii, (6-12); D., 

 Tll,v-xxx, (.3-2). 



Syrupus Scillw. Syrup of Squill. (U. S. & B. P.) 

 Made with vinegar of squill, 450; adding sugar, 800; straining and adding 

 water to make 1000. (U. S. P.) 



Dose.—H., gss, (15); D., 3ss-i, (2-4). 

 Incompatible with ammonium carbonate. 



Syrupus Scillw Oompositus. Compound Syrup of Squill. (U. S. P.) 

 Synonym.— Coxe's Hive Syrup. Fluidextract of squill, 80; fluidextract of 

 senega, 80; antimony and potassium tartrate, 2; distilled water, 10; syrup, q. s. 

 to make 1000. 



Dose.—D., ni,v-xxx, (.3-2). 



Pit. Ipecachuanhae cum Scilla. (B. P.) 

 Contains 6 per cent, opium. Dogs, gr.ii-viii. The compound syrup (U. S. 

 P.), or the pill of ipecac with squill (B. P.), is a good cough remedy for dogs. 



Action Internal. — Gastro-intestinal Tract. — Therapeutic doses do not 

 exert any effect, but toxic quantities cause vomiting and purging in dogs, 

 with fall of temperature, stupor, intermittent paralysis, convulsions, sup- 

 pression or scanty secretion of bloody urine, and death within 12 or 15 

 hours. Lesions of gastro-enteritis and congestion of the kidneys are 

 found after death. 



Circulation. — The action of squill on the heart and vessels is prac- 

 tically identical with that of digitalis. 



Respiration. — Clinical experience, rather than physiological experi- 

 ments, has shown that squill acts as an expectorant during its elimination 

 from the bronchial mucous membrane, thereby increasing secretion and 

 vascularity. 



Kidneys. — Squill is eliminated mainly by the kidneys, and in its ex- 

 cretion directly stimulates them and increases the amount of urine. In 

 toxic doses it produces acute parenchymatous nephritis and urinary sup- 

 pression. Squill is a more powerful diuretic than digitalis. 



Uses Internal. — Squill is useful in ascites of dogs, resulting from 

 valvular lesions or otherwise, to stimulate the heart and cause diuresis. 

 It may be given to advantage in pill with digitalis, calomel, and extract 

 of hyoscyamus — one grain of each. Small doses of squill are often ex- 

 hibited to dogs in the second stage of acute bronchitis, and occasionally 

 to horses, as an expectorant; and in large doses as an emetic for dogs in 

 the form of the simple or compound syrup. The drug is indicated in 

 bronchitis, with scanty secretion, or when exudation is excessive to 

 improve the tone of the bronchial mucous membrane. 



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