352 VKGETABLE DRUGS 



(b) Less Impurtaul Constituents. — (5) Kinic, or quinic acid (CjHijOc), occurs 

 in colorless prisms. Related to benzoic acid and eliminated in the urine as hip- 

 puric acid. Found in coffee beans and other vegetables. 



The alkaloids in cinchona are naturally united with kinic or kinovic acid, and 

 salts of this combination are used in medicine ; i.e., quinine kinate, which is soluble 

 and may be employed subcutaneously. 



(6) Kinovic, or quinovic acid (CaaHjiO,,), a white, amorphous substance 

 allied to kinovin. 



(7) Kinovin, or quinovin (C^jHisO.), a glucoside readily decomposed into 

 glucose and kinovic acid. 



(8) Cincho-tannic acid, or kino-tannic and kinovi-tannic acid (2-4 per cent.). 

 The astringent principle of cinchona. Distinguished from tannic acid in yielding 

 green color with ferric salts. 



(9) Cinchona red, the coloring matter of cinchona bark. Nearly insoluble in 

 water. 



(10) A volatile oil exi.sting in minute amount. 



(11) Starch, gum, resin and salts common to other vegetable matters. 

 Incompatibility. — Cinchona is incompatible with lime water, ammonia, metal- 

 lic salts or gelatin. 



Dose.— H., 3ii-iv, (8-15); C, si-ii, (30-60); Sh. & Sw., 5i-iv, (4-15); D. & C, 

 gr.x-3i, (.6-4). 



PREPARATIONS. 



Pluidextractum Ginclionic. Fluidextract of Cinchona. (U. S. P.) 

 Made by maceration and percolation with glycerin, HCl, alcohol and water, 

 and evaporation so that it shall contain 4.5 per cent, of total alkaloids of cin- 

 chona. (U. S. P.) 



Dose. — Same as cinchona. 



Extractum Cinchonir Liquidum. (B. P.) 



« Contains 4-5 per cent, of alkaloids. 

 Dose. — Same as cinchona. 



Infv^um Cinchonw Acidum. (B. P.) 

 Dose.—H., Oi, (500); D., 5ii-iv, (8-15). 



Tinctura Ciiichuiiic. Tincture of Cinchona. (U. S. & B. P.) 

 Made by maceration and percolation of cinchona, 200, with glycerin, 75; and 

 alcohol and water a sufficient quantity lo make 1000, 0.9 Gm. alkaloids in 100 mils 

 of tincture. (U. S. P.) 



Dose.—n., ,3i-ii, (30-60); D., .Iss-ii, (2-8). 



Cinchona Rubra. Red Cinchona. (U. S. P.) 



Cinchonae rubrae cortex, B. P. The dried bark of Cinchona succirubra Pavon 

 (Fam. RubiaceaB), containing not less than 5 per cent, of the alkaloids of red 

 cinchona. 



Habitat. ^EcaadoT, west of Chiraborazo. 



Description. — In quills or curved pieces of variable length, hark from 2 to 4 

 nun. in thickness, or in small broken fi-agme])ts or in transverselv curved pieces 

 from 3 to 7 mm. in thickness; externally gray, grayisli-brown or "reddish-brown; 

 odor slight; taste very bitter and astringent. Powder is light brown. 



Constituents. — Same as cinchona. 



Dose. — Same as cinchona. 



preparation. 

 Tinctura Cinchonw Compositus. Compound Tincture of Cinchona. (U. S. & B, P.) 



Made by maceration and percolation of red cinchona, 100; bitter orange peel, 

 80; serpentaria, 20; with glycerin, 75; and alcohol and water to make 1000. Con- 

 tains 0.45 per cent, of alkaloids of cinchona. (U. S. P.) 



Dose.—H., §ii-iv, (60-120); D., 3ss-iv, (2-15). 



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