QUININE 353 



'Quinine Sulphas. Quinine Sulphate. (CjoHjiO^N j)^ HaSOirfT HjO. 

 (U. S. 6s B. P.) 



Synonym. — Chininura sulfuricum, P. G. ; quinioe sulfas, or sulphate of quinia, 

 E. ; sulfate de quinine, Fr. ; sciiwefelsaures chinin, G. 



Derivation. — Prepared by boiling cinchona bark with hydrochloric acid and 

 adding lime to the filtered decoction to precipitate alkaloids and coloring matter. 

 The precipitate is washed and digested in boiling alcohol to dissolve quinine and 

 cinchonine. The alcohol is distilled off and the residue dissolved in diluted sul- 

 phuric acid, boiled with animal charcoal, filtered, and quinine sulphate crystallizes, 

 leaving cinchonine sulphate in solution. 



Properties. — White, silky, light, flexible, glistening crystals, making a very 

 light and easily compressible mass; or as hard, prismatic monoclinic needles; 

 odorless, and having a persistent and very bitter taste. It effloresces rapidly 

 when exposed to dry air, and then becomes lusterless; when exposed to light it 

 acquires a brownish tint. Soluble at 25° C. (77° F.), in 725 parts of water, and 

 in 107 parts of alcohol; also in 30 parts of glycerin; slightly soluble in chloroform 

 and ether; and freely in dilute acids. 



Incompatibles. — Alkalies and their carbonates, iodine, and tannic acid. 



Dose.—H. (tonic), gr.xv-3i, (1-4) ; C, 3ss-iss, (2-6) ; Sh. & Sw., gr.v-x, (.3-.6) i 

 D. & Cats, gr.i-ii, (.06-.12). Antipyretic Dose— H. & C, 3ii-iv, (8-15); Sh., 

 gr.xxx-xl, 2-2.6); Sw., gr.xv-xxv, (1-1.6); D. & Cats, gr.v-x, (.3-.6). 



Quinine Bisulphas. Quinine Bisulphate. CkHmOjNj H2S044-7 HjO. 

 (U. S. & B. P.) 



Derivation. — Made by the action of sulphuric acid on quinine sulphate sus- 

 pended in water; filtration and crystallization. 



Properties. — Colorless, transparent or whitish, orthorhombic crystals or small 

 needles; odorless, and having a very bitter taste; efflorescing on exposure to the 

 air, and turns yellow on exposure to light; soluble in 9 parts of water and in 23 

 parts of alcohol, and in 16 parts of glycerin. 



Dose. — Practically same as quinine sulphate, but theoretically it should be 

 slightly larger. The salt is very soluble, but is commonly made extemporaneously 

 by adding diluted sulphuric acid (Q. S.) to quinine sulphate in preparing solu- 

 tions for medicinal use. The salt is serviceable for administration in pill; or for 

 hypodermic injection, when it should be given in about one-third smaller dose 

 than that of quinine sulphate by the mouth. 



QuiiriN^ HYDROBnoMiDTjM. Quinine Hydrobromide. CjoHmNjOj H Br-f-HjO. 



(U. S. P.) 

 Derivation. — Made by the action of barium bromide, in solution, on quinine 

 sulphate suspended in water; filtration, evaporation, and crystallization. 



Properties. — White, light, silky needles; odorless, and having a very bitter 

 taste. The salt effloresces on exposure to air. , Soluble in 40 parts of cold water, 

 and in 0.9 part of alcohol; also soluble in 23 parts of ether, in 0.6 part of chloro- 

 form, and in 7 parts of glycerin. 

 Dose. — Same as quinine sulphate. 



tQtriNiN^ HYDBooiiLoaiDUM. Quinine Hydrochloride. CoHaO^Nj H Cl-l-2 HjO. 



(U. S. & B. P.) 



Derivation. — Made by the action of hydrochloric acid on quinine, and by 

 crystallization. 



Properties. — White, silky, glistening needles; odorless, and having a very 



bitter taste. The salt effloresces when exposed to warm air. Soluble in 18 parts 



*Tinc. Quininw Ammoniata (B. P.), from the sulphate. Dose. — H., Jss-l; 

 v., 3ss-i. 



■fTinctura Quininw (B. P.), from the hydrochloride. Dose, — H., ,^ss-i: O., 

 ^ss-i. 



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