64B GENERAL THERAPEUTIC MEASURES 



hogs in infected herds which at the time of treatment show a temperature 

 over 104° F. Such hogs and also those showing slight symptoms of 

 cholera should be injected with at least double the quantity of the im- 

 munizing dose. Animals showing distinct and severe symptoms of the 

 disease should not be treated. 



The simultaneous treatment consists of an injection of serum and a 

 corresponding dose of hog cholera virus in another part of the body. 

 This method of treatment confers to the animal a life immunity. It is 

 indicated in healthy herds where it is desired to prevent the development 

 of hog cholera; also in herds where the infection has already occurred, 

 in which instance the treatment should be applied only to hogs showing 

 no signs of the disease. 



It is important that hog cholera virus should never be injected with- 

 out the corresponding dose of anti-hog cholera serum. The two should 

 never be mixed together before injection and it is also essential to make 

 the injection of virus on the opposite side of the body, or at some distant 

 point to the serum injection. 



The serum is injected subcutaneously and preferably into the arm 

 pit (axillary region). With the clear, sterilized serum this location is 

 especially desirable since on account of the loose connective tissues in 

 this region an immediate absorption takes place. The serum may also 

 be injected in smaller hogs into the subcutaneous tissues of the groin. 



RABIES. 



Rabies is a fatal disease which is contracted through a bite from an 

 infected animal. At the present time the belief is growing that the cause 

 of rabies is a parasitic protozoan discovered by Negri and generally 

 known as the "Negri body." His discovery has been amply confirmed and 

 most observers agree with his interpretation as to the nature of these 

 bodies as well as on their significance. 



Dogs are in most instances responsible for the spread of the disease. 

 This is due to the fact that the affected dogs travel a long distance and 

 bite other dogs, as well as other animals and men. 



The period of incubation is from 16 to 40 days, although cases have 

 been reported as occurring as early as 14 days after natural infection and 

 as late as 60 days. Folk tales of the development of rabies many months 

 and even years after infection owe their origin to mistaken diagnoses or 

 to the disease due to an unobserved infection more recent than the sup- 

 posed inoculation. Certain prodromal symptoms may be noted by 

 changes in the dog's disposition, quiet friendly animals may become un- 

 easy and vicious and occasionally, the savage dog grows more affectionate. 

 In this prodromic period the owner may detect changes unnoticed by the 

 veterinarian. It should be noted that the bite of the dog is infectious 

 even at this stage and earlier before any symptoms whatever have devel- 

 oped. In the prodromic stage the dog is no more inclined to bite its 

 owner than when normal but is quite apt to snap at strangers. The 

 veterinarian must keep this in mind at all times in making examinations 

 of dogs. 



Death usually ensues in from three to seven days. The symptoms in 

 other animals vary with the species and with their natural weapons of 



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