PRINCIPLES OF VETERINARY SURGERY 291 



activity are formed. The proud^flesh — (granulation tissue) — ■ 

 appears in the wound, forming a rose-colored mass which 

 bleeds at the slightest contact. This is the germinative tis- 

 sue of Ziegler. From this moment the integrity of the tis- 

 sue is accomplished. The new products form a barrier 

 through which the microbian agents cannot traverse. In a 

 comparatively short time the granulations fill up the cavity 

 of the wound, its essential role being to bring the adjacent 

 structures to a level. At this moment there appears at the 

 periphery a whitish border of epidermic cells which gradually 

 covers the granulated surface. 



When the breach has been completely filled up with the 

 granulating tissue, sclerogenesis begins. The fibroblasts be- 

 come active and construct connective and elastic fibrillary 

 frameworks. This evolution occurs rapidly; the new cells 

 very speedily acquire adult life with "all its burdens and fa- 

 tigues." Promptly they become flattened, raveled, and 

 transformed into ordinary connective tissue cells, which are 

 not slow in exhibiting all the signs of a premature senility. 

 This cellular retrogression is accompanied by a. resolution of 

 new tissue. The capillaries flatten, atrophy, contract, and 

 disappear, leaving behind only traces of some cells. 



The cicatrix, thus completed, then changes its character. 

 Rose-colored at first, it later becomes white. It shrinks 

 more and more, becomes depressed, and on account of the 

 absence of hair follicles on its surface it leaves behind an 

 indelible blemish (retarded cicatrization). 



"Thus the scar tissue is produced. It is a tissue as dried 

 up as its generator — the granulating tissue — was succulent; 

 anaemic as much as the other was sanguineous; dense and 

 firm, thanks to its fibrous bundles, as much as its predecessor 

 was loose and incapable of much resistance ; and poor in cells 

 that are flat and even atrophied, as much as the granulating 

 tissue was living and richly cellular. In a word, the young, 



