432 PRINCIPLES OF VETERINARY SURGERY 



meter they become rare. They have been found in marshes, 

 in the slime of the Dead Sea, in the bogs of New Hebrides, 

 Santa Cruz, etc. In the Solomon Islands it is found in a 

 sort of earth which the natives use to poison their arrows. 

 La Danzea has shown that the wounds caused by . these 

 arrows are followed by tetanus. 



Tetanus spores are preserved while being carried along 

 by streams of water, creeks, rivers, etc. The bacilli abound 

 in dung, especially that of the horse, and are found pre- 

 served in the intestines of many animals. Animals fed with 

 earth-soiled substances, or tetanus cultures, have rejected 

 active bacilli without having died of the disease. The ex- 

 crement of the horse and cow inoculated into rabbits pro- 

 duces fatal tetanus in five to six days, showing that the 

 spores resist the action of the gastric juices. In animals 

 that have died from tetanus, the bacillus is always found 

 at the point of inoculation. They remain localized during 

 the entire progress of the disease and are not found either 

 in the blood or parenchymatous organs. Sanchez. Toledo 

 and Veillon have shown that they sometimes pass into the 

 general circulation a few hours before death. 



INOCULATION AND RECEPTIVITY.— The inocu- 

 lation of finished cultures gives tetanus to susceptible ani- 

 mals. The white mouse is highly susceptible. Cultures 

 forty-eight hours old, in doses of 1-500 of a cubic centimeter, 

 kill them after a short period of incubation. Eight hours 

 after inoculation in the paw tetanus appears, and at the end 

 of fourteen hours it becomes generalized. The cavy is also 

 very susceptible. Tetanus appears eighteen to twenty hours 

 after inoculation of 1-500 of a cubic centimeter. In the order 

 of susceptibility man comes after the cavy. The horse- is 

 killed with from one-half to one cubic centimeter after an 

 incubation of seven days. The mule is similar to the horse. 

 The rabbit offers more resistance, but, like the dog, is killed 



