168 IMPORTANT VARIETIES OP FISSION-FVNGL 



and then these demonstrations are not entirely free from 

 objection. 



As influencing the local infection, squamous epithelium 

 is a better protection than cylindric epithelium. The 

 parasite gradually passes through the epithelium into the 

 connective tissue and causes an irritation and inflamma- 

 tion there. No immunity follows recovery from the in- 

 fection. 



In migrating to distant regions of the body, the gono- 

 coccus especially follows the lymph spaces and causes in- 

 flammations, which lead to fibrous proliferation (for ex- 

 ample, urethral stricture). 



Experimental Pathologic Experiences. — In ani- 

 iinals : The results of inoculation are always negative. 

 Large quantities of culture cause toxin inflammations with- 

 out increase of the cocci, just as is done by the toxins 

 alone. 



In man : The production of gonorrhea and conjunctivitis 

 with pure cultures is easily accomplished. 



Special Methods of Recognition. — The following 

 peculiarities are to be demonstrated : Diplococci, lying in 

 clumps in the leuokcytes about the nuclei, staining with 

 methylene- blue, and not by Gram's method. Delicate 

 colonies in smears upon blood-agar and serum-agar. The 

 most positive control inoculation is upon the human 

 urethra. 



Varieties related to the Micr. gonorrhoeae. 



Several varieties have been partially studied by v. Bumm, which 

 may be mistaken for the Micr. gonorrhcEse because of their microscopic 

 form. We will only mention them, as we have not studied them, 

 and will refer to the work of Bumm, already spoken of, for further 

 details. 



Micrococcus albicans amplus. — Grows grayish-white upon gela^ 

 tin, and is larger than the Mic. gonorrhoefe. 



Diplococcus albicans tardissimus. — Microscopically is identified 

 morphologically with the Micr. gonorrhoeae, but grows upon gelatin, 

 although very slowly. 



Micrococcus subflavus. — See under Micr. pyogenes. 



Micrococcus melitensis (Bruce). 



Literature. — Durham, Jour, of Pathology, Vol. v, 1898, 377. 



