Diseases of the Liver and Spteen. 107 
in the detection of the same elements which had been ob- 
served in the former case. 
“No history was obtained in either instance, but there can 
be no doubt that the primary deposit occurred in the me- 
sentery in the first case, andin the spleen in the second, 
and that it was followed in both by cancerous infiltration into 
the structure of the liver.” 
BILIARY CALCULI. 
These are not unfrequently met with in canine practice, 
and, as already stated, are one of the causes operating in 
the production of jaundice. 
Symptoms.—The presence of biliary calculi is, as a rule, 
unattended with pain so long as their substance is small, 
and they can pass through the ducts without distending 
their walls; when, however, they become fixed, the pain 
is usually severe, and its seat denoted by the animal look- 
ing round towards the region of the liver, moaning and 
lying on the opposite side. Excessive vomiting and tor- 
pidity of the bowels, with flatulency and hiccup, attend this 
biliary impaction. When complete blocking of the duct 
takes place the bile is retained, and consequently re-ab- 
sorbed—hence jaundice. The feeces are nearly white, the 
urine of a deep orange colour. The pain is of a colicky 
nature; there is no inflammatory fever, increased respira- 
tion, or disturbed pulse, and the passage of calculi once 
effected, a restoration to usual health follows. 
Treatment.—This chiefly consists in relieving the pain 
during the passage of the calculi. Opium or aconite are 
the agents best adapted for this purpose ; 1 to 2 grains of 
the former, or I to 3 minims of the latter, every three hours. 
With regard to the administration of solvent agents for 
biliary calculi, nitro-muriatic acid, sulphuric ether, and 
carbonate of soda are each advocated and may be tried, 
but there is no direct proof that in passing through the 
