General Diseases. 349 
afterwards I heard from the owner that the favourite and 
valuable old dog was dead. This breed of bull-dogs is, I 
believe, now almost extinct ; they have been bred in-and-in. 
“ The examination of liver and heart led to the detection 
of avery unusual morbid change. The liver was dark in 
colour, speckled here and there with yellow granules. In 
form, the gland was almost globular ; in texture it was 
compact, with the consistency of an ordinary fatty tumour. 
On section the cut surface was granular, and mottled with 
minute yellow specks. A small portion of the enlarged 
organ was examined under the quarter-inch objective, and 
the liver-cells were observed to be filled with globules of 
fat. In addition, there was a considerable quantity of 
deposit of the nature of tubercle. 
‘The heart was also much enlarged ; the cavities of both 
ventricles were distended with coagulated blood. The walls 
were reduced in thickness to at least one half; and, under 
the microscope, the fibres were seen to be in the transition 
state between the nucleated cell form of the foetal struc- 
ture and the striated character of the fully developed 
muscle. Between the fibres there was a deposit of granular 
matter, identical in appearance with that observed in the 
liver. From the history of the case, there is good reason 
to believe that the puppy was the subject of scrofula, the 
result of hereditary transmission, intensified, and probably 
primarily induced, by the system of in-and-in breeding. 
The peculiar feature of the case is the existence of the 
deposit in the liver and heart—organs which are not ordi- 
narily affected to any serious extent in tuberculosis. The 
lungs, spleen, and kidneys were free from disease.”* 
GLANDERS. 
Fortunately, this scourge of horseflesh is but seldom met 
with in the dog. 
* From the Veterinarian, November, 1881. 
