General Diseases. 355 
no doubt as to the nature of the malady, which appeared 
in a most acute form. 
“Polli, of Milan, has induced the disease in dogs by depo- 
siting the virus in wounds or injecting it into the circula- 
tion. The effects were always apparent, but their intensity 
and gravity varied according to the mode of introduction. 
Prinz, Andral, Burguieres, Letenneur, Leblanc, Rayer, 
Saussier, and St. Cyr* have obtained results similar to those 
of Renault ; Lafosse has also several times successfully 
inoculated dogs with the glanders and farcy virus; and 
Decroix, from the result of his experiments, came to the 
conclusion that acute and chronic glanders are transmissible 
to the carnivora by inoculation.t 
“Some of the large carnivora, such as the lion, have re- 
ceived the disease through consuming the flesh of glandered 
horses.” 
* The results of inoculations practised upon seven dogs with glander 
matter, by Saint Cyr, of the Lyons Veterinary School, are summed up 
as follows :— 
‘61, Glanders is not the exclusive appanage of solipeds. 
‘2, It can certainly be transmitted to other animals, and especially 
to the dog, by inoculation. 
‘¢3, In the dog, as in the horse, it manifests itself by inflammation 
and ulceration of the inoculated wound, swelling of the lymphatic 
glands in its vicinity, and nasal discharge. Chancrous ulcers are, if 
not always, atleast generally, absent. 
‘ca, Glanders in the dog is generally remarkably benignant, and, ex- 
cept in those cases in which it has been injected into ine circulation, i it 
is perhaps seldom fatal. 
“5, Notwithstanding this marked benignity of ‘canine glanders,’ the 
virus none the less preserves all its activity, and, when retransmitted to 
the horse, inevitably produces the malady in as marked: a form as when 
passed direct from horse to horse. 
“6, Lastly, glanders in the dog, as in the horse, appears to be 
governed by the ‘law of unicity ;’ for with the horse actually glandered, 
and the dog successfully inoculated for the first time, inoculation with 
the most active glander virus produces no effect. This conclusion, 
however, requires more experiments to corroborate it.”—‘‘ Journal de 
Méd. Vét. de Lyon,” 1866, p. 307. 
+ “Journal de Méd. Vét. Militaire,” 1863. 
