shows an acid reaction. The substance does not change in color on 

 drying at 105° C. 



For combustion, the substance was mixed with fine copper oxide. 

 After drying at 105° C. in vacuum over phosphorus pentoxide it was 

 analyzed. 



The needle-shaped crystals gave the following: 



0.1534 gm. substance gave 0.0901 gm. H 2 and 0.3329 gm. C0 2 . 



0.2944 gm. substance gave 0.0702 gm. Mg. 2 P 2 7 . 



0.1175 gm. substance gave 6.75 cc. nitrogen at 22° C. and 763 mm. 



0.1688 gm. substance lost 0.0154 gm. H 2 on drying. 



0.1982 gm. substance lost 0.0183 gm. H 2 on drying. 



Found: C=59.18; H=6.57; P=6.64; N=6.56; H 2 0=9.12 and 9.23 

 per cent. 



The plate-shaped crystals gave the following : 



0.1786 gm. substance gave 0.0993 gm. H 2 and 0.3909 gm. C0 2 . 



0.4972 gm. substance gave 0.1089 gm. Mg 2 P 2 7 . 



0.1955 gm. substance lost 0.0256 gm. H a O on drying. 



0.5997 gm. substance lost 0.0783 gm. H 2 on drying. 



Found: C=59.60; H=6.22; P=6.10; H 2 O=13.09 and 13.05 per 

 cent. 



The compounds apparently do not represent any definite strych- 

 nine salt of inosite triphosphate but it would seem as if they were mix- 

 tures of the tri- and tetrastrychnine salts. 



For tri-strychnine inosite triphosphate, C H 15 O 15 P 3 (C 21 H 22 N 2 O l 2 ) s 

 = 1422. 



Calculated : C=58.23 ; H=5.70 ; P=6.54 ; N=5.90 per cent. 



For tetra-strychnine inosite triphosphate, C 6 H 15 15 P 3 (C 21 H 22 N : ;0 2 ) t 

 =1756. 



Calculated: C=61.50; H=5.86; P=5.30; N=6.37 per cent. 



PREPARATION OF THE BARIUM SALT FROM THE 

 STRYCHNINE SALT 



The recrystallized strychnine salt, 27 grams, was dissolved in 

 about 750 cc. of hot water and the solution rendered alkaline with 

 ammonia. After standing in ice water for some time the strychnine 

 was filtered off. The filtrate was shaken with several portions of 

 chloroform to remove the last trace of strychnine. 



The solution, which contained the ammonium salt of the organic 

 phosphoric acid, was precipitated by adding a solution of barium 

 chloride in excess. After settling over night, the precipitate was fil- 

 tered and washed several times with water. It was then dissolved in 

 1 per cent, hydrochloric acid, filtered and precipitated with barium 

 hydroxide in excess. The precipitate was filtered and washed with 



39 



