Acute Nephritis. Acute BrighV s Disease. 227 



cur in three days in the horse, and Trasbot in four days in a cow, 

 after a large cantharides blister. 



Pathological Anatomy. The kidney is enlarged, soft, friable, 

 dark red, yellow with red spots, or having areas of hemorrhage. 

 When fatty it is marbled, pale yellow or white and red. The cap- 

 sule is easily detached. On section it is bloody, oozing or even 

 dropping blood, or a pale creamy fluid. The pelvis contains 

 urine, thick, gelatinoid, bloody or purulent. The latter condi- 

 tion must not be confounded with the thick pus-like mucus which 

 normally occupies the renal pelvis in the horse. 



The lesions of the secreting portions of the kidney will vary 

 with the concentration of the inflammation in one or other of 

 the separate tissues. 



In glomerulitis from toxic irritants, the capsules enclose an 

 albuminous liquid exudate, the capillaries are overdistended, 

 their walls thickened and cloudy, and thrombi with an excess of 

 red globules and leucocytes block them at intervals. This capil- 

 lary obstruction extends to the plexus surrounding the convoluted 

 tubules. 



In tubular nephritis there is congestion of the plexus cover- 

 ing the convoluted tubes, and the epithelium shows cloudy swell- 

 ing, with fatty granules and hyalin droplets in the desquamating 

 cells. 



With interstitial nephritis there is an exudate into the in- 

 terstitial connective tissue between the tubules, and into the 

 . tubules forming hyaline casts. The epithelium of the tubules are 

 swollen, granular, opaque and desquamating. 



In suppurative nephritis may be found all stages of ab- 

 cedation from minute points, gray or yellow, and only just visible 

 to the naked eye, in the midst of the deep red congested tissues, 

 through the larger white suppurative areas, to the extensive 

 abscess formed by a coalescence of the many, the intervening 

 tissue having broken down by a necrotic disintegration. In the 

 earlier stages the pus infiltrates the parenchyma so that it may be 

 comparable to a sponge filled with this liquid, 



Treatment. The first consideration is rest, with a warm build- 

 ing or clothing to solicit the action of the skin and lessen the 

 work of the kidneys. Warm summer weather is favorable, or 

 we should secure a sunny, comfortable, loose box, or a building 



