330 PROTECTIVE INOCULATIONS. 
by the same rabid dog; and the mother of Meister, who had not been 
bitten. The child had been thrown down by the dog and bitten upon 
the hand, the legs, and the thighs, in all in fourteen different places. 
Pasteur commenced the treatment on July 6th, by injecting beneath 
the skin of this child an emulsion of cord which had been kept for 
fourteen days; this was followed by twelve more inoculations made 
on successive days with cord of increasing degrees of virulence—the 
last with cord a day old. On March Ist, 1886, Pasteur reported to 
the Academy of Sciences the fact that the boy Meister remained in 
good health and gave detailed information with reference to a number 
of cases which had since been treated by the same method. 
With reference to the duration of the immunity resulting from 
these inoculations Pasteur says (1886) that out of fourteen dogs in- 
oculated with “ ordinary street virus,” by trephining, at the expiration 
of a year after the protective inoculations had been practised, eleven 
resisted; out of six tested in the same way at the end of two years 
two proved to be immune. 
In November, 1886, Pasteur communicated to the Academy of 
Sciences the results of his experiments with reference to a modification 
of his method as at first employed—the so-called intensive method. 
This modification consisted in making the inoculations with cords of 
increasing virulence in more rapid succession. 
The method followed at Odessa, as reported by Gamaleia (1887), 
is shown below, the day being given above and age of the cord 
below. 
1 2 e 8 8. oF 2 Be 
14138 12-11 10-9 87 65 3 2-10 86 £4 BF 
Since the adoption of this method and the use of larger quantities 
of virus, according to Gamaleia, there have been no deaths among 
those inoculated, numbering more than two hundred at the time the 
report was made. The author last referred to concludes from his ex- 
perience that “the mortality diminishes in direct relation to the quan- 
tity of the vaccine injected.” 
Bujwid (1889) reports a total of 670 inoculations, with 9 deaths, 
made at Varsovie during the years 1886, 1887, and 1888. His method 
is shown below. 
oa 
1210 
2 Z 
8-6 3 
plo 
4 5 
3 6 
woo 
The results of inoculations made at the Pasteur Institute in Paris 
during the years 1886 to 1890 are given in the following table: 
