332 PROTECTIVE INOCULATIONS. 
“Tt is evident that the intensive treatment is very successful in coping 
with the worst cases, and that, instead of being itself a source of death, as 
asserted by those who gain notoriety and subsistence by villifying and mis- 
representing scientific progress, it is a powerful agent in saving life.” 
The following table is given by Horsely “as showing the contrast 
between the old or simple treatment and the intensive treatment”: 
Simple Treatment, 1886. Intensive Treatment, 1888. 
Odessa... ......0e ee eee 3.39 per cent. 0.64 per cent. 
WATSAW <4 ais iite apenas 4.1 a 0.0* “ 
Moscow.... ...seeeeee 82f * 1.6 
* The figures include sixteen months’ work, and thirty individuals bitten in the 
face—four by wolves. 
+ This unusually high rate was found to be due to imperfections in the manner 
of preparing the cords for the inoculation material. 
Perdrix (1890), in an analysis of the results obtained at the Pasteur 
Institute in Paris, calls attention to the fact that the mortality among 
those treated has diminished each year and ascribes this to improve- 
ment in the method. He says: 
‘* At the outset it was difficult to know what formula to adopt for the 
treatment of each particular case. Upon consulting the accounts of the bites 
in persons who have died of hydrophobia notwithstanding the inoculations, 
we have arrived at a more precise determination as to the treatment suitable 
for each case, according to the gravity of the lesions. In the cases with seri- 
ous wounds we inject larger quantities of the emulsion of cord and repeat the 
inoculations with the most virulent material. For the bites upon the head, 
which are especially dangerous, however slight their apparent gravity may 
be, the treatment is more rapid, and, above all, more intensive—that is to 
‘say, the virulent cord is injected several times.” 
The statistics arranged with reference to the location of the bite 
are given by Perdrix as follows: 
Bitten upon the head, 684; died, 12 = 1.75 per cent. 
- = “hands, 4,396; “ §=— 92 ae 
re . “ limbs, 2,889; “ 5=017 “ 
Other methods of making susceptible animals immune against 
hydrophobia have been proposed and proved by experiment to be 
successful. Thus Galtier in 1880-1881 claimed that the sheep and 
the goat could be protected by intravenous injections of the virus of 
rabies, and more recent experiments fully confirm this. Protopopoff 
(1888) by injecting an emulsion of cord from a rabid animal into the 
circulation of dogs succeeded in protecting them from hydrophobia 
as a result of subsequent inoculation with virulent material upon the 
surface of the brain. He injected into a vein, at intervals of three 
days, one cubic centimetre of an emulsion of cord—first of six days, 
second of three days, third of one day. Roux had previously accom- 
plished the same result by a single intravenous injection of a larger 
