PROTECTIVE INOCULATIONS. 3865 
favorable as regards an immunizing or curative effect from inocula- 
tions of tuberculin in rabbits. Dénitz, on the contrary, arrives at the 
conclusion that when early treatment is instituted iris tuberculosis 
may be arrested and cured, and the more recent experiments of Tru- 
deau (1893) give support to this conclusion. Baumgarten, however, 
insists that the tuberculin treatment does not prevent metastasis to 
the lungs after inoculations in the anterior chamber of the eye. 
Pfuhl (1891) treated forty-seven infected guinea-pigs, and at the 
date of his report forty-four had died tuberculous, but the date of 
death was somewhat postponed by the treatment. The animals not 
treated succumbed at the end of eight weeks (average of all controls), 
and those treated with small doses of tuberculin lived, on the average, 
ten weeks. With larger doses still more favorable results were ob- 
tained—tour lived on an average twelve weeks, and three were still 
living, eleven, fifteen, and sixteen weeks after infection, at the date of 
publication. 
Kitasato (1892) also obtained favorable results in the treatment 
of infected guinea-pigs, and arrives at the conclusion that guinea-pigs 
which have been cured by the treatment are not susceptible to a sec- 
ond infection, for a certain time at least. 
Bujwid (1892), in experiments upon guinea-pigs, found that in- 
fected animals which received from 0.05 to 0.1 gramme of tuberculin 
within three hours showed an elevation of temperature of 1.5° to 2° C. 
Thirteen infected guinea-pigs treated with tuberculin lived from two 
and a half to eight months, while all of the control animals (eighteen) 
died in from six to nine weeks. The animal which survived eight 
months was found not to be tuberculous, but presented evidence of re- 
covery from a former tuberculous process. In two rabbits inoculated 
in the anterior chamber the iris tuberculosis was favorably influenced 
by the tuberculin treatment, but general infection occurred, and the 
animals died about the same time as the controls. Three apes were 
treated without any apparent result; they all died within two months 
after infection. 
The experiments of Gramatschikoff, Czaplewski, and Roloff, and 
of Yamagiva, published in 1892, show that the tuberculin treatment 
does not cure tuberculous infection in inoculated guinea-pigs and rab- 
bits, and that the bacilli retain their vitality in such animals in spite 
of the most persistent treatment. 
Héricourt and Richet (1892), in experiments made for the purpose 
of immunizing animals against tuberculous infection, failed to obtain 
positive results in the most susceptible species—guinea-pigs, rabbits, 
and apes—but claim to have succeeded in immunizing dogs by intra- 
