BACTERIA IN CROUPOUS PNEUMONIA. 3uy 
in their blood a multitude of oval microérganisms, united for the 
most part in pairs, or in chains of three or four elements. These 
experiments are recorded in my paper entitled ‘‘ Experimental Inves- 
tigations Relating to the Etiology of the Malarial Fevers,” published 
in the Report of the National Board of Health for 1881, pp. 74, 75. 
Following up my experiments made in New Orleans (in Septem- 
ber, 1880), in Philadelphia (January, 1881), and in Baltimore (March, 
1881), I obtained the following results : 
‘‘ The saliva of four students, residents of Baltimore (in March), 
gave negative results ; eleven rabbits injected with the saliva of six 
individuals in Philadelphia (in January) gave eight deaths and three 
negative results; but in the fatal cases a less degree of virulence was 
shown in six by a more prolonged period between the date of injec- 
tion and the date of death. This was three days in one, four days 
in four, and seven days in one.” 
In a paper published in the Journal of the Royal Microscopical 
Society (June, 1886) I say : 
“* My own earlier experiments showed that there is a difference in 
the pathogenic potency of the saliva of different individuals, and I 
have since learned that the saliva of the same individual may differ 
in this respect at different times. Thus during the past three years 
injections of my own saliva have not infrequently failed to cause a 
fatal result, and in fatal cases death is apt to occur after a some- 
what longer interval, seventy-two hours or more; whereas in my 
earlier experiments the animals infallibly died within forty-eight 
hours.” 
The presence of my Micrococcus Pasteuri was demonstrated in 
the blood of the rabbits which succumbed to the inoculations. 
Claxton, in a series of experiments made in Philadelphia in 1882, 
injected the saliva of seven individuals into eighteen rabbits. Five 
of these died within five days, and nine at a later period. 
Frankel, whose first publication was made in 1885, discovered 
the presence of this micrococcus in his own salivary secretions in 1883, 
and has since made extended and important researches with refe- 
rence to it. The saliva of five healthy individuals and the sputa 
of patients suffering from other diseases than pneumonia, injected 
into eighteen rabbits, induced fatal ‘‘sputum septicemia” in three 
only. When he commenced his experiments his saliva was uni- 
formly fatal to rabbits, but a year later it was without effect. 
Wolf injected the saliva of twelve healthy individuals, and of 
three patients with catarrhal bronchitis, into rabbits, and induced 
“ sputum septicaemia ” in three. 
Netter examined the saliva of one hundred and sixty-five healthy 
persons, by inoculation experiments in rabbits, and demonstrated 
the presence of this micrococcus in fifteen per cent of the number. 
