THE BACILLUS OF ANTHRAX. 429 
tured as a result of the distention, and the bacilli, together with 
escaped blood corpuscles, will be seen in the surrounding tissues. In 
the kidneys the glomeruli, especially, appear as if injected with col- 
ored threads, and by rupture these may find their way into the urini- 
ferous tubules. 
These appearances and the general symptoms indicate that the 
‘disease produced by the introduction of this bacillus into the bodies of 
susceptible animals is a genuine septicemia. As in other forms of 
septicaemia, the spleen is found to be greatly enlarged ; it has a dark 
color and is soft and friable. With this exception the organs pre- 
sent no notable changes, although the liver is apt to be somewhat 
enlarged. Inthe guinea-pig an extensive inflammatory cedema, ex- 
tending from the point of inoculation to the most dependent parts of 
the body, is developed ; the subcutaneous connective tissue is infil- 
trated with bloody serum and has a gelatinous appearance. This 
animal comes next to the mouse in susceptibility, and cultures which 
Fig. 103.—Bacillus anthracis in kidney of rabbit. x 400. (Baumgarten.) 
are attenuated to such an extent that they will not kill a rabbit or a 
sheep may still kill a guinea-pig ; or, if not, may killamouse. Pasteur 
has shown that the pathogenic power of the bacillus may be reéstab- 
lished by inoculations into susceptible animals, and that an attenu- 
ated culture which will not kill an adult guinea-pig may be fatal to 
a very young animal of this species, and that cultures from the blood 
of this will have an increased pathogenic virulence. 
Very minute quantities of a virulent culture are infallibly fatal to 
these most susceptible animals, but for rabbits and other less sus- 
ceptible animals the quantity injected influences the result, and re- 
