462 BACTERIA IN DIPHTHERIA. 
or simultaneously received an injection of a streptococcus culture— 
filtered or unfiltered. 
Results of Treatment with the Antitoxin.—While questions re- 
lating to therapeutics are not considered in this manual, a brief note 
upon the results of treatment by the serum of immunized animals 
may not be out of place. A collective investigation (1895) un- 
‘dertaken by the Deutsche medicinische Wochenschrift gave the 
following results: The number of cases collected was 10,312; all of 
these occurred between the 1st of October, 1894, and the Ist of April, 
1895; 5,883 of these cases were treated with the antitoxin and 4,479 
without it. In the first group the mortality was 9.6 per cent, and in 
the second group 14.7 per cent. Two thousand five hundred and fifty 
six children treated with the antitoxin were between two and ten 
years of age; among these the mortality was 4 per cent, while 
among children of the same age not treated with the antitoxin the 
mortality was 15.2 per cent. Six hundred and ninety-six patients 
above ten years of age were treated with a mortality of 1 per cent. 
Monod (1895), at a meeting of the Paris Academy of Medicine, 
presented the following statistics demonstrating the influence upon 
the mortality from diphtheria in France exerted by the antitoxin 
since its employment from November, 1894. The following figures 
represent the number of deaths from diphtheria during the first six 
months in eight years in 108 French cities having a population of 
more than 20,000: 
1888-94, 1895. 
Average. Average. 
SABUALY sec te sso 4G. Hise Wee Lea eter eed on Se as 469 205 
Februar yiiis: ccs. ca viwseieay 1220405 50s Mee ewe we see es 466 187 
Mareh:. $5.00 civ cnkve So PS a08 MA OHRSR AE owe eoN ES oe 155 
SPT ivat deep snesei pod 8ctek soaks euwtoine Wiedaspoe © aigus lage ay woes 44 160 
AMER Yiscde< cosshsrie ca patcvavavanecaiaan nsavaunronse sedgcan boo: exbsora te cousebusteonisesce ata teasss A17 1138 
UG a sesork jak a diacsnaava wai aavaveseesaia a3 Cah ava satrap Racal. 333 84 
2,656 904 
It will be seen from the above statement that during the first six 
months in the year 1895 after the introduction of the antitoxin treat- 
ment, the number of deaths from diphtheria in the 108 French cities 
referred to was 1,552 less than the average for the preceding ten 
years, and we are justified in concluding that a considerable propor- 
tion of this saving at least is due to this method of treatment. 
