518 BACILLI WHICH PRODUCE SEPTICEMIA 
nies appear as spherical, grayish-brown discs, the surface of which is marked 
with dark points or lines. The superficial colonies are more transparent, 
have irregular outlines, and the surface, especially near the margins, 1s 
coarsely granular. The development in stab cultures is very rapid and re- 
sembles that of Friedlander’s bacillus—‘“‘ nail-shaped” growth. Upon potato 
the growth is also similar to that of Friedlainder’s bacillus, and consists of a 
thick, grayish-white, moist, and shining layer. 
Pathogenesis.—Mice inoculated with a small quantity of a pure culture 
die from acute septicaemia in about forty-eight hours. The bacilli are found 
in blood from the heart and from the various organs—most numerous in 
the liver. Rabbits are killed within forty-eight hours by intravenous injec- 
tion of a small quantity, and the blood contains the bacillus in great num- 
bers. Larger amounts injected into the circulation of rabbits or dogs cause 
death in a few hours (three to ten), preceded by diarrhcea, and in some in- 
stances bloody discharges from the bowels. At the autopsy an acute gastro- 
enteritis is found, 
BACILLUS PYOGENES FCETIDUS. 
Obtained by Passet (1885) from an abscess of the anus. 
Morphology.—Short bacilli with rounded ends, 1.45 mu long and 0.58 u 
broad; usually associated in pairs or in short chains. 
Biological Characters.—An aérobic, non-liquefying, motile bacillus. 
Grows rapidly in the usual culture media at the room temperature. In the 
interior of the rods, in stained preparations, one or two unstained, spherical 
places may sometimes be seen, which have been supposed to be spores (?). 
The independent motion exhibited by this bacillus is not very active. In 
gelatin plates white colonies are developed at the end of twenty-four hours, 
which upon the surface spread out as grayish-white plaques, having a dia- 
meter sometimes of one centimetre; these are thickest in the centre and of 
a whitish color; the colonies may become confluent. In gelatin stab cul- 
tures the growth upon the surface, at the end of twenty-four hours, consists 
of a thin, grayish white layer with rather thick, irregular margins; along the 
line of puncture more or Aes crowded colonies. Upon potato the bacillus 
forms an abundant, shining, pale-brown layer. The cultures give off a dis- 
agreeable putrefactive odor. 
According to Hisenberg, mice and guinea-pigs are killed in twenty-four 
hours by injections beneath the skin or into the cavity of the abdomen, and 
numerous bacilli are found in the blood. 
PROTEUS HOMINIS CAPSULATUS. 
Obtained by Bordoni-Uffreduzzi (i887) from two cadavers presenting the 
pathological appearances of the so-called ‘‘ Hadernkrankheit.” 
Morphology.—Bacilli, varying considerably in dimensions; somewhat 
thicker than the anthrax bacillus; often swollen in the middle or at the ex- 
tremities; more or less curved; isolated, united in pairs or in long filaments; 
in stained preparations from agar cultures or from blood the bacilli are sur- 
rounded by a ‘‘ capsule.” 
Stains with the usual aniline colors and also by Gram’s method. 
Biological Characters.—An aérobic (facultative anaérobic 2), non-lique- 
Fying, non-motile bacillus. Formation of spores not observed. Grows in 
the usual culture media at the room temperature. A+ a temperature of 15° to 
17° C. long filaments are formed, in which the bacilli are surrounded with a 
capsule; at 22° to 24° C. the bacilli are for the most part isolated, but few fila- 
ments being formed ; at 32° to 37° C. the bacilli are so short as to resemble 
Teerences development ceases at a temperature of 8° and is very slow at 
