viii CONTENTS 



CHAPTEB IV. 



METHODS OF SPREAD OF DISEASE— IMMUNITY— BACTEBIAL 

 TOXINS— SEEO-THEEAPT. 



PAGE 



Methods of spread of disease— Epidemics— Methods of bacterial 

 action — The antagonism of micro-organisms — Immunity — 

 Hypotheses of immunity— The exhaustion or pabulum, antidote 

 or retention, and acquired tolerance hypotheses — Methods of 

 producing artificial immunity — Metabolic products of the 

 growth of pathogenic bacteria — Ptomaines — Isolation of pto- 

 maines — Toxalbumoses, bacterial proteins — Sero-therapy — 

 Eesearches of Behring, Kitasato, Tizzoni and others on anti- 

 toxins — Defensive proteids or alexias — Preparation of diph- 

 theria antitoxin — Preparation of the toxias — Immunisation of 

 the animals — Standardisation and preparation of the serum — 

 Preparation of antitetanic, antistreptococcic, antivenomous and 

 other sera - ' - - 102-137 



OHAPTEE V. 



TUBEECULOSIS. 



The baoiUus of tuberculosis : discovery and morphology of the 

 organism — Growth on artificial media — Bacteriological diag- 

 nosis — Staining of the bacUli in sputum and in sections — 

 Pastor's cultivation method — Number of bacUli in sputum — 

 Occurrence and distribution of tuberculosis — Infection of air, 

 dust, meat, mUk, etc. — Evidence given before Eoyal Commis- 

 sion on tuberculosis — Resistance of the bacilli to desiccation — 

 Pathogenesis — Special regulations in force in New York and 

 Germany — Presence of tubercle bacilli in air of hospital wards, 

 etc. — Identity of human, avian and boviae tuberculosis — 

 Bang's method for eliminating tuberculosis from cattle — Koch's 

 tuberculin treatment of consumption — Preparation of tuber- 

 culin — Practical disinfection. 



lEPEOSY. 



Discovery and morphology of the organism— Staining in sections 

 -Distribution of the bacilli in the body— Growth on artificial 

 media— Conveyance of disease — Leprosy in India Commission 

 Eeport — Occurrence and distribution — Pathogenesis — Preven- 

 tive measures. 



