CHOLERA 213 



gastric juice. This immunity of animals is no evidence 

 whatever against the pathogenicity of the organism for 

 man, as there are many other organisms which produce 

 disease in man to which the lower animals are immune. 



Haflfkine's Vaccine Treatment. — This treatment has been 

 tried on several thousands of persons in India, and it 

 may fairly claim to have passed the experimental stage 

 successfully. The results reported are much more success- 

 ful than those that have hitherto attended the antitoxin 

 treatment for diphtheria. 



Haffkine administers two injections — the first of at- 

 tenuated vaccine, and a second of stronger vaccine at the 

 end of five days. This second dose requires five days to 

 act before the full power of immunisation that it exerts is 

 effected. 



With reference to the employment of this remedy and 

 its effects, as observed during an outbreak of cholera in 

 a certain district in Calcutta, Dr. Simpson, Medical Officer 

 of Health of Calcutta, says that ' after eight days — in fact, 

 after five days — the difference in liability to attack is very 

 marked, the inoculated living in the same houses in Cal- 

 cutta being twenty times safer from attack and eighteen 

 times securer from death should cholera enter the house. 

 This is protection of a very decided character.' No cases 

 of cholera occurred among those who subjected themselves 

 to both inoculations. We must, however, bear in mind 

 that any person who has been persuaded to adopt this 

 prophylactic measure is probably well informed on the 

 subject of cholera, and fully alive to the wisdom of boiling 

 drinking-water and avoiding uncooked vegetables, and may, 

 therefore, be in the habit of using precautions neglected by 

 the majority. 



Preparation of Antiolioleraic Vaccine. — The object of this 

 treatment is the acclimatisation of the system to a greater 



