HYDROPHOBIA 271 



they are inert and useless. When required for human 

 inoculation, about 1 cm. of the dried cord is taken, and 

 triturated as finely as possible with a glass rod, in a test- 

 glass, then mixed with about 10 cm. of broth, adding it 

 slowly until a complete emulsion is made. The paper 

 cover is then again placed over the top of the glass, and 

 the emulsion is ready for injection. The inoculation is 

 made in a fold of the skin of the stomach, on account of 

 the subcutaneous cellular tissues at this part being looser, 

 and thus more rapidly absorbent. About 1 c.c. of the 

 above emulsion would be an ordinary dose, but this varies 

 according to the age and condition of the patient. The 

 duration of treatment depends entirely upon the gravity of 

 the bites received, mild cases being treated for from fifteen 

 to sixteen days, whilst more severe ones receive inoculations 

 for a longer period — extending up to twenty-one days, and 

 during the first three or four days of such cases inocula- 

 tions are often made twice daily. In all cases, however, 

 the mode of procedure is the same, beginning with cords 

 of thirteen or fourteen days, and gradually working down 

 by degrees to those of onp, two, or three days old, as con- 

 sidered necessary. After inoculation each patient has his 

 wounds examined and dressed by an attendant. No special 

 dieting is required, the patient being simply recommended 

 to "lead a steady and moderate life. The inoculation gives 

 little or no pain, and is not attended by any swellings 

 or redness as a rule. It is of course essential that all 

 vessels, instruments, etc., which are used in the prepara- 

 tion of the cords and their subsequent inoculation, should 

 be strictly sterile, and every possible aseptic precaution 

 taken. 



The following are the returns of the inoculations made, 

 as a preventative against rabies, at the Pasteur Institute 

 for the past ten years {Annales de VInstitut) : 



