TOXICOLOGY 291 
somewhat. Liver dark. Spleen pale. Pancreas enlarged and in- 
filtrated. Heart is systole. Considerable food in crop. 
(2) February 28,1918, 10 a.m. Gave fowl 1% drams of sodium 
nitrate. 1.30 p.m. No change is apparent. 3.30 p.m. Fowl 
bunched up and sleeping. On being aroused displays marked thirst. 
Becomes droopy and sleepy again. 4.30 p.m. Fowl droopy and 
shows thirst. March 1, 9 a.m. Fowl quiet. Sits down. Comb 
and wattles dark red. 12 m. Same as above. 1.30 p.m. Fowl 
paralyzed, no use of feet, prostrated. 3.30 p.m. Same as above. 
Comb blackening at the tips. 4.30 p.m. Same as above. March 
2, 9 a.m. Fowl up, normal in appearance but quiet on being 
handled. Comba bright red. 3P.m. Fowl apparently normal. 
(3) June 25,10 4.m. Gave fowl 44 dram of sodium nitrate. Re- 
sult. No effect was apparent. 
STRYCHNINE SULPHATE 
Lethal dose. 2 grains to 3% pound fowl. 
Toxic dose. 2 to 3 grains to 5 pound fowl. 
1.5 grains to 3 pound fowl. 
8 ce. F. E. nux vomica = 1.2 grains to 3 pound fowl. 
Non-toxic dose. 2 grains to 5 pound fowl. 
Experiments. (1) August 12, 2.22 p.m. Gave 3% pound fowl 
2 grains of strychnine sulphate in gelatin capsule per os. 2.30 P. M. 
Breathing more rapidly. Some unsteadiness of legs. 2.31 P.M. 
Convulsion lasting 10 seconds. Fowl down on side. 2.382 P.M. 
Slight convulsion. Rapid breathing. 2.35 p.m. Slight convul- 
sion. 2.36P.M. Fowl stretched out at length. Rapid shivering of 
legs. 2.40 p.m. Fowl dead. Autopsy notes. Fowl stiff. Con- 
siderable fluid in crop. Heart in systole. Liver slightly congested. 
Comb, wattles and face darkened. 
(2) August 12, 2.23 p.m. Gave 5 pound fowl 8 grains of strych- 
nine sulphate in gelatin capsule per os. 2.45 p.m. Breathing 
rapidly. Unsteady on legs. 2.50 p.m. Sitting, 2.55 P.M. 
Standing. Breathing 180 per minute. 3.45 p.m. Breathing con- 
siderably decreased. Some unsteadiness on legs through lack of 
normal powers of balance. 4.30 ».m. Appears improved. August 
13, 9 a.m. Fowl’s legs straddled. Cannot stand up. When dis- 
turbed clonic spasms lasting 4 or 5 seconds are set up. August 14, 
9 a.m. Fowl paralyzed. August 15, 9 a.m. Fowl stands fairly 
erect for a short time but is unsteady on its feet. Diarrhea present. 
