16 OSSEOUS CACHEXIA. 



Abundance or ai^parent richness of food signifies nothing if quality is 

 kicking. 



It may also be asked : if the question of nourishment is of such prime 

 importance ^Yhy are animals of European origin in Cochin-China 

 affected, whilst the indigenous races prove immune? The answer 

 would appear to be that, in addition to the defective quahty of food, 

 other factors, such as adaptation to environment and relative digestive 

 power, play a considerable part in the production of the disease. 



Favouring causes. Whilst conceding that the disease is due to one 

 determining cause, viz. the food, it is unquestionable that other causes 

 may favour its appearance. Abundant milking is one, so that the 

 disease most frequently appears six to eight weeks after calving. Gesta- 

 tion may also determine an attack. The disease is rarer in oxen than in 

 milch cows. Starvation and bad hygienic conditions also have a certain 

 influence; it is well known that during dry years, particularly when 

 fodder is scarce, osseous cachexia makes the greatest ravages. Law 

 states that the disease has been attributed to excess of organic matter in 

 the soil, to succulent watery foods, as rank watery grasses, potatoes, 

 turnips and other roots deficient in nutritious solids. Some agent — 

 microbe or toxin — swallowed with the food has been suspected but not 

 yet isolated. 



Other explanations have been advanced but up to the present time 

 they scarcely deserve to be regarded even as hypotheses. Thus Anacker 

 in 1865 declared that the disease commenced as muscular rheumatism, 

 was succeeded l)y destructive or atrojihic ostitis, and ended as osteo- 

 porosis. So far as the order of the osseous lesions is concerned, this 

 view is quite correct, l)ut the ossific changes are consequences and not 

 causes. 



The idea that the disease was due to an infectious agent has been 

 advocated by Leclainche, without, however, having been proved. 

 Petrone is the only person who has hitherto suggested that osteo- 

 malacia in man is due to infection with a nitric ferment (Micrococcus 

 nitrijiccDiH). According to him, pure cultures of this organism injected 

 into dogs, produce osteomalacia. These statements, however, require 

 confirmation. 



Lesions. The chief lesions are to be found in the bones. They 

 consist in rarefaction of the compact tissue, increase in size of the 

 medullary cavity and Haversian canals, and enlargement of the areolae 

 of the spongy tissue. The bone marrow loses its fatty constituents, 

 appears red and gelatinous, and contains a greatly exaggerated number 

 of blood-vessels. When heated, the bones do not yield oil as in healthy 

 subjects, and when dry, they seem abnormally porous. In the osteo- 

 clastic phase, the bones liecome very friable and even the shafts assume 



