INFECTIOUS DISEASES. 549 
tion, remaining for some time as a local sore, which may then heal, 
leaving a perfectly sound animal; but while the local sore is con- 
tinuing to ulcerate, and specific virus exists in it, it may be the car- 
rier of contagion to other animals. In man we find a greater recep- 
tivity to glanders than in the dog, and in many unfortunate cases 
the virus spreads from the point of inoculation to the entire system 
and destroys the wretched mortal by extensive ulcers of the face and 
hemorrhage or by destruction of the lung tissue; in other cases, 
however, glanders may develop, as in the dog, in local form only, 
not infecting the constitution and terminating in recovery, while the 
specific ulcer by proper treatment is turned into a simple one. In 
the feline species glanders is more destructive than in the dog. The 
point of inoculation ulcerates rapidly and the entire system becomes 
infected. , 
While a student the writer saw a lion in the service of Prof. 
Trasbot, at Alfort, which had contracted the disease by eating glan- 
dered meat and died with the lung riddled with nodules. A litter of 
kittens lapped the blood from the lungs of a glandered horse on which 
an autopsy was being made, and in four days almost their entire 
faces, including the nasal bones, were eaten away by rapid ulcera- 
tion. Nodules were found in the lungs. A pack of wolves in the 
Philadelphia Zoological Garden died in 10 days after being fed with 
the meat of a glandered horse. The rabbit, guinea pig, and mice 
are especially susceptible to the inoculation of glanders, and these 
animals are convenient witnesses and proofs of the existence of sus- 
pected cases of the glanders in other animals by the results of suc- 
cessful inoculations. 
The primary lesion in any form is a local point in which occurs 
a rapid proliferation of the cell elements which make up the animal 
tissue with formation of new connective tissue, with a crowding to- 
gether of the elements until their own pressure on one another cuts off 
the circulation and nutrition, and death takes place in them in the 
form of ulceration or grangrene. Following this primary lesion we 
nave an extension of infection by means of the spread of the bacilli 
into those tissues immediately surrounding the first infected spot, 
which are most suitable for the development of simple inflammatory 
phenomena or the specific virus. The primary symptoms are the re- 
sult of specific reaction at the point of inoculation, but at a later time 
the virus is carried by means of the blood vessels and lymphatic ves- 
sels to other parts of the body and becomes lodged at different places 
and develops in them; again, when the disease has existed in the 
latent form in the lungs of the animal and the virus is wakened into 
action from any cause, we have it carried to various parts of the body 
and developing in the most susceptible regions or organs. The points 
of development are most frequently determined by the activity of the 
