350 SMALL -POX. 



subjects -which recovered was 28,248, and the number which 

 died was 285 — or about one per cent. M. Gayot inoculated 

 10,000 in the departments of La Marne and La Haute Marne 

 during the prevalence of the disease, when the mortality was 

 twenty per cent, among those having it in the natural way ; 

 and he lost only one and one half per cent, of his patients. 

 Messrs. Miquel and Thomieres inoculated between December, 

 1820, and January, 1822, 17,044 sheep, comprising eighty-four 

 flocks, and forty-two of them infected ones. In some of the 

 flocks not previously infected they did not lose a patient. Li 

 one, in which two-thirds of the sheep were already attacked 

 by the disease, they lost about eight per cent, of the remaining 

 number, many of which were doubtless .in the incubatory 

 state of the disease when inoculated. Out of 66,716 inocu- 

 lated in Prussia, 65,042 recovered. Out of 8,000 sheep and 

 2,000 lambs inoculated in Austria, not one was lost. These 

 examples might be indefinitely multiplied. 



D'Arboval states that 7,697 sheep which had received the 

 disease by inoculation and recovered, had been re-inoculated, 

 made to cohabit with sheep laboring under the natural 

 disease, &c., &c., and that in no instance did they again 

 contract the malady. 



Mr. Youatt declares that variola ovina is not identica. 

 with small-pox in the human being. He says there is an 

 evident diflference in the pustule — that of small-pox being 

 " developed in the texture of the skin, and surrounded by a 

 rose-colored areola, that of the clavellee evidently more deep- 

 seated — reaching to the sub-cutaneous cellular tissue and 

 surrounded by an areola of a far deeper color. The virus of 

 small-pox was usually contained in a simple capsule which 

 elevated the scarf skin — the virus of the sheep-pox seemed 

 to be more difiiised through the cutaneous and sub-cutaneous 

 tissue, and there was abundantly more swelling and inflamma- 

 tion." He describes other differences in the appearance of 

 the matter, scabs, &o.* » 



Vaccination followed the introduction of inoculation. To 

 test their respective usefulness, 1,523 sheep were vaccinated 

 in France, and the disease became fuUy developed in them. 

 They were all subsequently inoculated with the virus of sheep- 

 pox, and 308 took the disease, though in the-mitigated form 

 usual after inoculation. Other smaller experiments had a 

 corresponding result ; and, therefore, says Mr. Youatt — at 



* I Bnppoae that Mr, Touatt in expressing these opinions, expresses the opinions 

 of the learned veterinarians of the Continent. 



