CONTENTS 



IV 



Contents: Various examples of the effects of stimulation. Metab- 

 olism of rest and metabolism of stimulation. Metabolic equilib- 

 rium. Disturbances of equilibrium by stimuli. Quantitative and 

 qualitative alterations of the metabolism of rest under the influ- 

 ence of stimuli. Excitation and depression. Specific energy of 

 living substance. Qualitative alterations of the specific metab- 

 olism and their relations to pathology. Functional and cytoplastic 

 stimuli. Relations of the cj^oplastic effects of stimuli to the func- 

 tional. Hypertrophy of activity and atrophy of inactivity. Meta- 

 bolic alterations during growth of the cell. Primary and second- 

 ary effects of stimulation. Scheme of effects of stimulation. . . 65 



Contents: Indicators for the investigation of the process of excitation. 

 Latent period. The question of the existence of assimilatory exci- 

 tations. Dissimilatory excitations. Excitations of the partial 

 components of functional metabolism. Production of energy in 

 the chemical splitting up processes. Oxydative and anoxydative 

 disintegration. Theory of oxydative disintegration. Dependence 

 of irritability on oxygen. Experiments on unicellular organisms, 

 nerve centers and nerve fibers. Restitution after disintegration by 

 metabolic self-regulation. Organic reserve supplies of the cell. 

 The question of a reserve supply of oxygen of the cell. Metabolic 

 self-regulation as a form of the law of mass effect, and metabolic 

 equilibrium as a condition of chemical equilibrium. Functional 

 hypertrophy 87 



VI 



Contents: Only processes of excitation are conducted, not processes of 

 depression. Conduction of excitation in its two extreme instances. 

 Conduction in undifferentiated pseudopod protoplasm of rhizopoda. 

 Conduction of excitation with decrement of intensity and rapidity. 

 Conduction of excitation in the nerve. Rapidity of conduction. 

 Conduction of excitation without decrement. Relation between 

 irritability and conductivity. Conduction of excitation with decre- 

 ment of the nerve after artificial depression of irritability by nar- 

 cosis. Theory of the decrementless conduction of the normal 

 nerve. Proof of the validity of the "all or none law" in the 

 medullated nerve. Theory of the process of the conductivity of 

 excitation. Theory of core model (Kernleiter). Electrochemical 

 theory of conduction based on the properties of semi-permeable 

 surfaces. ... . . ... ... . . 118 



