532 PROTOZOAL DISEASES. 



liypodermic syringe of appropriate size or by using a lioUow 

 needle attached by an indiarrubber tube to a funnel into which 

 the solution is poured, as in giving an intravenous injection of 

 " 606." 



Innumerable investigations have been made on arsenic prepara- 

 tions, the main results are that different strains of trypanosomes 

 vary in virulence and act differently to various preparations, in 

 the rapidity with which they are destroyed, and to the extent to 

 which they become proof against arsenic. Consequently, it is 

 usual to vary the form of arsenic, such as starting with soamin 

 and continuing with arsenious acid in alkaline solution. The use 

 of antimony for trypanosomiasis is still in the experimental stage. 



Dourine ( Covering Disease, Mai du Coii). 



I have compiled the majority of the following remarks on this 

 disease from Friedberger and Frohner's " Pathologie," and from 

 Cagny and Gobert's " Dictionnaire Vet6rinaire." 



DEFINITION. — Dourine is a specific disease which at first ap- 

 pears as an inflammation of the surface of the genital organs, and 

 which causes grave alterations in the nervous system of the 

 attacked animal. Under natural conditions, it is confined to the 

 horse, ass, and their hybrids ; although it can be conveyed to 

 dogs and other animals. It runs either a chronic or acute course, 

 the former being more common than the latter. Mares are more 

 liable to acute dourine than stallions. 



GEOGRAPHICAJL DISTRIBUTION.— It was first observed in 

 Germany by Ammon in 1796, and has since th^t time spread to a 

 greater or less extent, through Germany, Austria, Russia, Italy, 

 France, Algiers, Syria, and America. As far as I have been able 

 to learn, it is unknown in Great Britain, Ireland, the Indian 

 Empire, China, and Australasia. Roll states that it is not met 

 with in Belgium. " Dourine appears on rare occasions in the 

 South of France, and is frequently met with in Spain and Algeria " 

 (Cagny and Gohert). 



MODE OF PROPAGATION.— It is a purely contagious disease ; 

 that is, it can be transmitted only by contact, and under all ordi- 

 nary circumstances, only during- the act of coition, from stallion 

 to mare, and vice versa. The inoculation of fresh blood is the 

 most effective means of transmitting dourine. 



NATURE OF THE DISEASE.— In 1896, Dr. Rouget showed 

 that dourine is a true infective disease caused by trypanosoma 

 equiperduBJ, 



