628 MEDICINES. 



suffering from glanders, the tumour continues to increase iu size 

 to about the thirtieth hour after inoculation ; it persists for two or 

 three days ; then gradually recedes, and does not finally disappear 

 until the fifth or sixth day. Inflamed lymphatic glands may be seen 

 radiating from the tumour, which may be so painful as to cause 

 lameness of the fore leg of the side upon which it is situated. 

 These remarks specially apply to a glandered horse which has 

 been injected with mallein for the first time, and is under 

 conditions that are favourable for this test. 



Although little or no swelling may be visible at the .seat of 

 the injection, the fact that reaction has taken place locEilly may 

 be clearly manifested by the painful condition of the part. The 

 absence of well-marked swelling is often caused by the injection 

 having been made too deeply. The appearance of the swelling 

 is occasionally delayed for two, and even for three days iu 

 exceptional cases. Kepeated injections often have the effect of 

 diminishing the size of the swelling, and may also delay its 

 appearance. 



The rise of temperature (at least 2.5° F. and sometimes as great 

 as 6° or even 7° F.) is characterised by the fact, that having 

 reached its maximum in about 15 hours, it does not disappear 

 until about 24 or 30 hours after inoculation. If the horse is free 

 from glanders, the temperatm'e will not be affected. 



If, at the time of inoculation, the temperature be high — say, 

 102° F. or more — ^the reactions may be less apparent, or altogether 

 wanting in an affected animal. Two cases have been recorded of 

 horses whose respective temperatures were 103.1° F. and 103.4° F., 

 at the time of inoculation. Their temperatures fell, instead of 

 rising; the condition of the swelling at the seat of inoculation 

 was normal, being about the size of a walnut ; the appetite of 

 one of them continued good ; and yet both of them were proved 

 by post-mortem examination to be thoroughly infected with 

 glanders. 



A decided opinion should not be passed, unless both reactions 

 take place ; although an exaggeration in one may make up for a 

 deficiency in the other. A local reaction is much more diagnostic 

 than a rise of temperature. Some authorities regard them as 

 equally important. 



The better the reactions are m.arked, the stronger will be the 

 suspicion that glanders is present. 



A horse may fail to react, on account of the shortness of time 

 between infection and this test, in which case the period of latency 

 is probably less than a week. In one series of experiments, 

 Nocard infected four horses by feeding, and when he tested them 

 with mallein on the sixth day afterwards, the reaction was so 



