BACTERIOLOGY IN A NUTSHELL. 



Dose. 



Observation of 

 Symptoms. 



Bacterin by 

 Mouth. 



ing such cases has brought into use thf mixed 

 bacterins. Dose varies from 25,000,000 to 

 250,000,000 staphylococci. It is conceded by 

 authorities to be wise to start treatment by ad- 

 ministering a small dose and to increase accord- 

 ing to indications. If a proper size dose has 

 been administered the patient feels better for 

 an hour or two, then follows a period of depres- 

 sion with increase of the local symptoms, 

 known as the "negative phase" (Wright). This 

 should last a day or two, when improvement 

 follows. The period of improvement runs from 

 four to twenty days — known as the "positive 

 phase." Should no "negative phase" occur, the 

 dose is too small. If the "positive phase" is very 

 severe, or should it last longer than three days, 

 the dose is too large. The dose is not increased 

 so long as the "negative phase" continues. 



Administration of the bacterin by mouth has 

 been discussed, but it is thought that not enough 

 efficient work has been accomplished to make 

 this method advisable. 



The site of injection recommended is a point 

 from whence the lymph drains through or past 

 the local lesion. 



Dr. Hartwell of the Massachusetts General 

 Hospital reports good results in that institu- 

 tion in the treatment of localized staphylococcus 

 infections by bacterins. 



Dr. Pray in the Edinburgh Medical Journal 

 192 



