no Veterinary Medicine. 



At the end of twenty-four hours the symptoms are intensified 

 or altered. The eyelids are more swollen and the flow of tears 

 more profuse ; the nasal discharge becomes slimy, and streaked 

 with blood, and accumulations take place in the frontal sinuses as 

 indicated by the increasing heat of the forehead and the dullness 

 on percussion. In the mouth appear dark red spots, from blood 

 extravasation, over which the epithelium sloughs off leaving raw 

 unhealthy sores. The appetite entirely fails ; dung and urine are 

 passed painfully and with effort, and abortion frequently takes 

 place in pregnant cows. The urine is albuminous with cell forms, 

 and casts. The limbs appear rigid and it pains the animal to move. 



From the fourth to the sixth day the ulceration appears on the 

 mucous membrane of the nose which has often a claret color, and 

 the nasal discharge becomes again more watery and irritating. 

 The muzzle is swollen and a dropsical infiltration appears beneath 

 the jaws, which extends along the neck to beneath the thorax and 

 into the limbs. Portions of the nasal mucous membrane now 

 slough off, and similar sloughs are often seen on the skin of 

 different parts of the body ; the secreting structures of the horns 

 and hoofs even participating, so that these are easily detached 

 or shed. Saliva flows profusely from the lips, a fetid watery 

 diarrhoea succeeds the constipation, the dropsy becomes nearly 

 general and death occurs on the eighth, ninth or tenth day of the 

 illness. Convulsions and symptoms of suffocation may precede 

 death. 



In a post mortem section the principal lesions are found in the 

 nasal cavities and skin. The areolar tissue in both is the seat of 

 an abundant serous infiltration, which has taken place into the 

 deeper layers of the skin as well, rendering it thick, hard and 

 unyielding. Besides the sloughs and ulcerations on the skin and 

 mucous membranes, false membranes have been met with, on the 

 lining membrane of the mouth and air passages. The ulcers in 

 the nose have in many cases reached the bone, and from the 

 abundant infiltration and softening, the membrane is easily 

 stripped from the walls of this cavity and of the sinuses. The 

 general infiltration appears to have reached the brain, which is 

 described as softened and having an undue amount of liquid in 

 its cavities. The blood contained in the vessels is dark colored 

 and numerous patches of extravasation are visible on the mucous 

 and serous membranes as well as in the interior of organs. 



