536 Veterinary Medicine. 



great number of nucleated or double nucleated lymphocytes, free 

 nuclei and granules which stain strongly. 



Hardened sections show an enormous development of the 

 follicles at the expense of the medullary walls, and double nu- 

 cleated white globules packed in a rich reticulum of adenoid tis- 

 sue, whilst the blood-vessels in the connective tissue are crowded 

 with white cells, and there are slight ruptures, old or recent. 



Lesions of the Spleen. These are nearly always present. 

 I^eisering found a horse's spleen over three feet long and 28 ibs. 

 weight, and Nocard one of 13 lbs. Bollinger found a pig's spleen 

 3}^ lbs. Siedamgrotzky found dog's spleens over 2 lbs. The 

 consistency is usually firm (sometimes soft in dog). Capsule 

 thickened and white, cut surface dry, reddish brown, granular, 

 Malpighian bodies enlarged like a pea, hazel nut or walnut, with 

 contents as in the lymph follicles. The capillaries are enlarged 

 and crowded with white cells. 



Lesions in the Liver. The liver is enlarged in one-half of 

 the cases of leukaemia in the lower animals. It has been found 

 to weigh 20 lbs. in the horse, and 4 lbs. in the dog. It is of a 

 grayish brown, or yellowish brown hue, or light red spotted with 

 yellow, or mapped out by anastomosing grajdsh white lines. 

 There may be enlargement of the acini, or the formation of little 

 nodes of adenoid tissue, or most commonly in the lower animals, 

 there is an adenoid thickening of the bands of connective tissue 

 extending in from the capsule. These are filled with white cells 

 which stain deeply with carmine. There may also be slight ex- 

 travasations of blood and infarcts. 



Lesions in the Bone Marrow. These noticed in the pig by 

 Fiirstenberg, and in dogs by Siedamgrotzky, consist in increased 

 vascularity, great cell hjrperplasia, and formation of adenoid 

 tissue as described under leukaemia. 



Lesions of the Intestine. These commence in the agminated 

 or solitary glands, which become enlarged, causing thickening 

 of the mucous membrane, and later grow out into more or 

 less rounded masses of lymph — adenoid tissue up to an inch in 

 thickness. They are quite subject to ulcerations. 



Lesions of the Tonsils. Bollinger, Nocard and Siedam- 

 grotzky found these enlarged in dogs in connection with adenoma 

 of the spleen. They were soft, friable, grayish, and consisted of 

 a very delicate and fragile adenoid tissue. 



