INFECTIOUS TUMORS. 255 



in such. And concludes that they may be divided into three stages : 



"1. The early granulation-tissue stage — i. e., a filling out of the 

 shrunken connective-tissue cells. 



"A stage in which the granulation-tissue cells have assumed the 

 characters of sarcoma-cells. Some of these cells exhibit a mitotic 

 activity comparable to that seen in the earlier stages of invasion 

 of the cells of the cornea by the protozoa of vaccinia in their 

 hyaline or chromidial phase. Among the tumour-cells in this stage 

 are bodies of typical protozoon characters; and — 



"3. A final stage in which chromidial parasites escape from the 

 nuclei of the tumor-cells, rapidly enlarge, become nucleated, and 

 subdivide; this process terminates in the formation of minute 

 bodies, most of which are in the chromidial condition." 



Treatment. In the male it is comparatively easy. If the 

 tumor has not broken down it should be removed by filling the 

 prepuce with cocaine solution, then have an assistant retract the 

 prepuce and expose the free portion of the penis. The tumors 

 must be freely cut away with a pair of curved scissors; then to 

 the excised portion of tissue apply the thermo-cantery, or with a 

 camel's hair brush apply pure carbolic acid which should be 

 neutralized immediately with an alkaline solution. There is always 

 considerable hemorrhage, but this is easily controlled. French 

 advises if there should be great hemorrhage,, to take one or two 

 stitches in the mucosa. This is io be done only where the 

 hemorrhage is extreme and the stitches to be removed not later than 

 twenty-four hours afterwards as the sutures cause great irritation. 

 The non-irritating substitutes for nitrate of silver such as the 

 silver proteids and albuminates are particularly useful in this 

 condition and should be applied locally in the male and injected 

 freely in solution in the bitch. 



The male, if treated early, generally recovers in three, or four 

 months, in the bitch if the vagina is involved to any great extent 

 it is not wise to breed her. If asked to give an opinion as to her 

 purchase as a brood bitch it would be well to advise against it. 



