DIABETES MELLITUS. 259 



alterations ia the size of the spleen and lymphatic glands. In 

 the glands of the head and neck we may find considerable enlarge- 

 ment, as is also the case with the testicles. It is somewhat hard 

 to really detect an abnormal enlargement of the mesenteric lym- 

 phatic glands; while tumors of the spleen may occasionally be 

 detected by manipulation, it is only when 

 they have reached a very much enlarged 

 condition (Fig. 58). "Various observers 

 have mentioned other symptoms, such as 

 increase of the pulse (130 to 140 per min- 

 ute); loss of appetite; the buccal mucous 

 membrane is red and inflamed, and the ^™ ^ ^^g,™ 

 tongue is coated. In rare instances, diar- /^^^J*' 



rhoea and dropsical symptoms may be The bio^d in iencocyth«>mia. 

 present. The disease is generally chronic, 



and death may occur after several months as the result of total 

 exhaustion. 



Therapeutic Treatment. The agents generally used by 

 physicians in the treatment of this affection are iron, quinine, 

 iodine, and bromine, but, as a rule, none of these produce favor- 

 able results. Arsenic seems to have answered better than any 

 of the others, and is, therefore, to be recommended for dogs. 

 Besides the disease just described, we have a condition which is 

 very rarely seen in a dog — " pseudo-leukaemia." In this condi- 

 tion we see exactly the same hyperplasia of the lymphatic glands 

 as in true leukaemia, but there is no increase in the white blood- 

 corpuscles (Frohner). One case which was observed by the 

 author was that of an old setter dog which showed considerable 

 hyperplasia of the lymphatic glands of the neck and trunk; also 

 acute anaemia. There was not any enlargement of the spleen or 

 the lymphatic glands of the abdominal cavity. 



Diabetes Mellitus. 



Etiology. By diabetes mellitus we understand a peculiar 

 abnormal condition of the urine which contains a large quantity of 

 sugar. The true cause of this peculiar disease is not exactly known, 

 but from observations which have been made on dogs and other 

 animals it is supposed to be due to a partial paralysis of the vaso- 



