b 



90 



At 3.30 p. m. vomited the remainder of his dinner. 



It will be seen from the temperature chart that during this time 

 his temperature was rapidly, rising and reached its highest point 

 (38,7° C.) at 4 o'clock p. m., just two hours and twenty minutes aiter 

 receiving the injection. 



The pains in the knees and back continued, and nausea and vomit- 

 ing now became a distressing feature of the paroxysms for the patient. 



The fever gradually subsided, and reached normal at 4.30 a. m. that 

 same night. (See temperature chart.) 



As the fever subsided the skin became moist, the nausea and pains 

 gradually disappeared, so that by 6 o'clock p. m. the patient was quiet 

 and dozing. The entire paroxysm, therefore, according to the tem- 

 perature record, lasted about eight hours, although the patient was 

 sleeping quietly five hours after receiving the injection. 



It is interesting to note that this man Peredo had what seemed to 

 be a typical malarial paroxysm beginning with a distinct rigor asso- 

 ciated with a rise of temperature and followed by slight sweating. It 

 is of particular interest to note that his paroxysm, so far as symptoms 

 were concerned, was very much like the paroxysm from which Andres 

 Mendez suffered, especially the nausea and vomiting. 



Peredo was kept under very close scrutiny until November 24, 

 eighteen days following the injection, during which time he remained 

 entirely normal and no plasmodium appeared in his peripheral blood, 

 which was frequently examined, as follows : 



Blood examination. — Goldhorn's stain. 



November 6. — 1.30 p. m., 8 p. m. No malaria. 



November 7. — 4.30 a. m., 8.30 a. m., 12.30 p. m., 5 p. m., 11 p. m. No malaria. 



November 8. — 7 a. m., 1 p. in., 6 p. m., 9.30 p. m. No malaria. 



November 9. — 7.30 a. m., 1.30 p. m. No malaria. 



November 10. — 2 a. m., 3.30 p. m., 8. p. m., five minutes each. No malaria. 



November 11. — i, 7, 10 a, m., 2, 6, 11 p. m., five minutes each. No malaria. 



November 12. — 1.30, 6.25 a. m„ five minutes each. No malaria. 



November 13.— 7 a. m., 9.30 p. m., five minutes each. No malaria. 



November 1%. — 8 a. m., 8 p. m., five minutes each. No malaria. 



November 15.— 8 a. m., 8.30 p. m., five minutes each. No malaria. 



November 16. — 7 a. m., 9.30 p. m., five minutes each. No malaria. 



November 17.— 8 a. m., 8 p. m., five minutes each. No malaria. 



Jose Ojeira (case XXIII), a volunteer from Jalapa, 18 years old; 

 had never lived on the coast, and says he never had fever of any kind. 

 On examination in Jalapa, August 11, he was found to be physically 

 sound, of robust physique; urine showed no albumin, and blood exam- 

 ination for malaria was negative. 



^ He was taken to Vera Cruz August 13, and immediately trans- 

 ferred to a mosquito-proof room in the laboratory, where he was 

 kept under close observation. 



