Monilia Candida, Robin (1847). 



THEUSH fungus; oidium albicans, sacchaeomycbs albicans; 

 MUGUET {Fr.); SOOEPILZ (©erm.).' 



Origin. — Pound in thrush on the mucous membrane in 

 the mouths of infants and of grown persons; also in air, in 

 milk, in barns; occurs as a white growth on cow-dung. It 

 may occasionally be found on mucous membrane other-than 

 that of the mouth. 



Form. — Occupies an intermediate position between the 

 moulds and yeasts. On gelatin plates and on sugar media 

 it forms yeast-like cells (conidia), whereas in the deeper 

 part of a stab culture it forms mycelial threads. The 

 mycelial threads are developed best in the absence of sugar 

 and at a high temperature. 



Anilin dyes. — Stain readily. 



Growth. ^Is rapid and abundant. 



Plates. — Snow-white, coarsely granular colonies form on gelatin 

 plates and no liquefaction takes place. 



Stab culture.— In gelatin show a slight growth along the line of in- 

 oculation, while on the surface a milk-white, thick mass forms. 



Streak cultv/re. — On agar, forms a glistening, moist, thick, white 

 growth. On potato, it grows rapidly as a thick, white, yeast-like mass. 



Oxygen requirements. — It is an aerobe. 



Temperature. — Grows at the ordinary temperature; also 

 in the incubator at 40°. 



Behavior to gelatin. — It does not liquefy. 



Pathogenesis. — Intravenous injection in rabbits pro- 

 duces death in 1-2 days; with very small doses death may 

 not result for a week or two. The internal organs are 

 sometimes permeated with a growth of long mycelial 

 threads. Under rare conditions it has been found in the 

 internal organs of man. When inoculated into the throat 

 •of doves and chickens it produces a typical thrush-mem- 

 brane. Subcutaneous application of a few mg. will produce 

 death in white mice in 1-3 days. It has no effect on guinea- 

 pigs. The identity of Monilia Candida with thrush cannot be . 

 said to be fully established. 



It ferments cane-sugar and maltose without previous 



inversion, and in time may give rise to about 5 per cent, of 



alcohol. 



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